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Analysis of drug-related problems in a healthcare facility IV.
Gajdošová, Vanesa ; Doseděl, Martin (advisor) ; Kalafutová, Stanislava (referee)
(english) ANALYSIS OF DRUG-RELATED PROBLEMS IN HEALTHCARE FACILITY IV. Author: Vanesa Gajdošová Supervisor: PharmDr. Martin Doseděl, Ph.D. Introduction Drug-Related Problems (DRPs) occure in lots of clinical areas.1 They are defined as pharmacotherapy related events, which actually or prospectively interfere with a therapeutic purpose.2 Aims The goal of the teoretical part of the work is to become familiar with the problem of DRPs and analyze in detail the problems of benzodiazepines and atipsychotics. The practical part of the work is focused on obtaining and evaluating of DRPs in the specific healthcare facility. Methods The data was obtained in Hamzova odborná léčebna pro děti a dospělé (Luže-Košumberk) which is the important center of rehabilitation in the Czech Republic. The audit was taking place from February 13, 2017 to February 16, 2017. The data of 94 patients from the three departments of the rehabilitation center was analyzed. The all necessary information was obtained from the medical documentation. The data was collected using the special online application and finally was statistically evaluated by the descriptive statistic. The most occurred DRPs were discussed with physicians. Results Patients used together 672 drugs (i.e. 7.15 drugs per patient). Overall, 272 DRPs were registered...
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Derivatives of Rhodanine as Potential Drugs III
Kalafutová, Stanislava ; Opletalová, Veronika (advisor) ; Zimčík, Petr (referee)
Diploma thesis Rhodanine derivatives as potential drugs III. Stanislava Kalafutová In the first part of the diploma thesis there is generally written about different types of tuberculosis in the various aspects as ethiology, pathogenesis and pharamacotherapy. The second part is focused on the newly tested potential antituberculotic drugs. Especially in the third part there are mentioned different drug targets of these promising antituberculotics. Finally the fourth part of the theoretical introduction briefly summarizes currently used drugs in the treatment of this infectous disease. The experimental work deals with number of synthesis of following compounds: 5-(3-bromobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(2- bromobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(3-chlorobenzylidene)-2- thioxo-1,3-thiazolidine-4-one, 5-(2-chlorobenzylidene)-2-thioxo-1,3-thiazolidine- 4-one, 5-(4-fluorobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(3- fluorobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(2-fluorobenzylidene)-2- thioxo-1,3-thiazolidine-4-one, 5-(pyridine-4-ylmetylidene)-2-thioxo-1,3- thiazolidine-4-one, 5-(pyridine-3-ylmetylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(furane-2-ylmetylidene)-2-thioxo-1,3-thiazolidine-4-one. All synthesized compounds were tested for an antifungal and antibacterial...
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Analysis of drug-related problems in a healthcare facility IV.
Gajdošová, Vanesa ; Doseděl, Martin (advisor) ; Kalafutová, Stanislava (referee)
(english) ANALYSIS OF DRUG-RELATED PROBLEMS IN HEALTHCARE FACILITY IV. Author: Vanesa Gajdošová Supervisor: PharmDr. Martin Doseděl, Ph.D. Introduction Drug-Related Problems (DRPs) occure in lots of clinical areas.1 They are defined as pharmacotherapy related events, which actually or prospectively interfere with a therapeutic purpose.2 Aims The goal of the teoretical part of the work is to become familiar with the problem of DRPs and analyze in detail the problems of benzodiazepines and atipsychotics. The practical part of the work is focused on obtaining and evaluating of DRPs in the specific healthcare facility. Methods The data was obtained in Hamzova odborná léčebna pro děti a dospělé (Luže-Košumberk) which is the important center of rehabilitation in the Czech Republic. The audit was taking place from February 13, 2017 to February 16, 2017. The data of 94 patients from the three departments of the rehabilitation center was analyzed. The all necessary information was obtained from the medical documentation. The data was collected using the special online application and finally was statistically evaluated by the descriptive statistic. The most occurred DRPs were discussed with physicians. Results Patients used together 672 drugs (i.e. 7.15 drugs per patient). Overall, 272 DRPs were registered...
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Analysis of drug-related problems in a healthcare facility IV.
Gajdošová, Vanesa ; Doseděl, Martin (advisor) ; Kalafutová, Stanislava (referee)
(english) ANALYSIS OF DRUG-RELATED PROBLEMS IN HEALTHCARE FACILITY IV. Author: Vanesa Gajdošová Supervisor: PharmDr. Martin Doseděl, Ph.D. Introduction Drug-Related Problems (DRPs) occure in lots of clinical areas.1 They are defined as pharmacotherapy related events, which actually or prospectively interfere with a therapeutic purpose.2 Aims The goal of the teoretical part of the work is to become familiar with the problem of DRPs and analyze in detail the problems of benzodiazepines and atipsychotics. The practical part of the work is focused on obtaining and evaluating of DRPs in the specific healthcare facility. Methods The data was obtained in Hamzova odborná léčebna pro děti a dospělé (Luže-Košumberk) which is the important center of rehabilitation in the Czech Republic. The audit was taking place from February 13, 2017 to February 16, 2017. The data of 94 patients from the three departments of the rehabilitation center was analyzed. The all necessary information was obtained from the medical documentation. The data was collected using the special online application and finally was statistically evaluated by the descriptive statistic. The most occurred DRPs were discussed with physicians. Results Patients used together 672 drugs (i.e. 7.15 drugs per patient). Overall, 272 DRPs were registered...
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Derivatives of Rhodanine as Potential Drugs III
Kalafutová, Stanislava ; Zimčík, Petr (referee) ; Opletalová, Veronika (advisor)
Diploma thesis Rhodanine derivatives as potential drugs III. Stanislava Kalafutová In the first part of the diploma thesis there is generally written about different types of tuberculosis in the various aspects as ethiology, pathogenesis and pharamacotherapy. The second part is focused on the newly tested potential antituberculotic drugs. Especially in the third part there are mentioned different drug targets of these promising antituberculotics. Finally the fourth part of the theoretical introduction briefly summarizes currently used drugs in the treatment of this infectous disease. The experimental work deals with number of synthesis of following compounds: 5-(3-bromobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(2- bromobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(3-chlorobenzylidene)-2- thioxo-1,3-thiazolidine-4-one, 5-(2-chlorobenzylidene)-2-thioxo-1,3-thiazolidine- 4-one, 5-(4-fluorobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(3- fluorobenzylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(2-fluorobenzylidene)-2- thioxo-1,3-thiazolidine-4-one, 5-(pyridine-4-ylmetylidene)-2-thioxo-1,3- thiazolidine-4-one, 5-(pyridine-3-ylmetylidene)-2-thioxo-1,3-thiazolidine-4-one, 5-(furane-2-ylmetylidene)-2-thioxo-1,3-thiazolidine-4-one. All synthesized compounds were tested for an antifungal and antibacterial...
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