|
|
Inflammatory and Fibrotic Myocardial Involvement
Šedivý, Jakub ; Hromádka, Milan (advisor) ; Mayer, Otto (referee) ; Pařenica, Jiří (referee)
1 Inflammatory and fibrotic myocardial involvement MUDr. Jakub Šedivý, Kardiologické oddělení FN Plzeň Introduction: The aim of my work was to evaluate the comprehensive approach to diagnosis and eventually monitoring the trend in two cardiac diseases of non-ischemic etiology. The first part is focused on evaluation of the inflammatory changes in patients with "infarct-like" myocarditis based on magnetic resonance (MRI) and laboratory tests. We also considered the possibility of restricting the length of physical activity restriction by bicycle ergometry. The second topic was the comprehensive assessment of cardiac risk in patients with systemic sclerosis, including the assessment of possible MR and new laboratory markers of myocardial fibrosis. Materials and methods: In the first part, we included prospectively 30 patients with "infarct- like" myocarditis and with a positive finding of late gadolinium enhancement (LGE) on MRI. Follow up MRI, echocardiography and stress ECG were performed at 1 and 6 month intervals. In the study focused on systemic sclerosis, a total of 33 long-term patients were prospectively enrolled. The study included a comparison of a group of 20 healthy volunteers. Results: In 47% of patients with infarct-like myocarditis, we found a left ventricular dyskinesia, but only 17% of...
|
|
|
Risk factors for atherosclerosis and its potential pharmacological effects in patients with coronary artery disease and lower limb
Hromádka, Milan ; Filipovský, Jan (advisor) ; Piťha, Jan (referee) ; Šimon, Jaroslav (referee)
1 Statin therapy in patients with peripheral artery obstructive disease (PAOD) 1.1 Patients with lipid metabolism disorders Simvastatin therapy with the dose titration adjusted to the effect led to the prolongation of claudication interval and to the elevation of ankle-brachial pressure index, which was statistically significant at the interval of 18 months after starting the therapy. At the same time we observed normalization of lipid levels and the lowest levels of oxidative stress markers. Statin use was also associated with lowering homocysteine level. 1.2 Patients without lipid metabolism disorders - the influence on laboratory parameters and functional capacity In patients without lipid metabolism disorder, treated with simvastatin 20 mg daily, we noted an improvement, i.e. prolongation of claudication interval and elevation of ankle-brachial pressure index, while in the control group treated only with a diet we observed further deterioration of capacity. In the control group, the parameters of lipid metabolism were statistically significantly worse after six months and this trend remained even in further control visits with HDL cholesterol slightly lowering. In the simvastatin group, a statistically significant decrease of LDL occurred during several months as well as elevation of HDL...
|
|
|
Inflammatory and Fibrotic Myocardial Involvement
Šedivý, Jakub ; Hromádka, Milan (advisor) ; Mayer, Otto (referee) ; Pařenica, Jiří (referee)
1 Inflammatory and fibrotic myocardial involvement MUDr. Jakub Šedivý, Kardiologické oddělení FN Plzeň Introduction: The aim of my work was to evaluate the comprehensive approach to diagnosis and eventually monitoring the trend in two cardiac diseases of non-ischemic etiology. The first part is focused on evaluation of the inflammatory changes in patients with "infarct-like" myocarditis based on magnetic resonance (MRI) and laboratory tests. We also considered the possibility of restricting the length of physical activity restriction by bicycle ergometry. The second topic was the comprehensive assessment of cardiac risk in patients with systemic sclerosis, including the assessment of possible MR and new laboratory markers of myocardial fibrosis. Materials and methods: In the first part, we included prospectively 30 patients with "infarct- like" myocarditis and with a positive finding of late gadolinium enhancement (LGE) on MRI. Follow up MRI, echocardiography and stress ECG were performed at 1 and 6 month intervals. In the study focused on systemic sclerosis, a total of 33 long-term patients were prospectively enrolled. The study included a comparison of a group of 20 healthy volunteers. Results: In 47% of patients with infarct-like myocarditis, we found a left ventricular dyskinesia, but only 17% of...
|
|
|
Risk factors for atherosclerosis and its potential pharmacological effects in patients with coronary artery disease and lower limb
Hromádka, Milan ; Filipovský, Jan (advisor) ; Piťha, Jan (referee) ; Šimon, Jaroslav (referee)
1 Statin therapy in patients with peripheral artery obstructive disease (PAOD) 1.1 Patients with lipid metabolism disorders Simvastatin therapy with the dose titration adjusted to the effect led to the prolongation of claudication interval and to the elevation of ankle-brachial pressure index, which was statistically significant at the interval of 18 months after starting the therapy. At the same time we observed normalization of lipid levels and the lowest levels of oxidative stress markers. Statin use was also associated with lowering homocysteine level. 1.2 Patients without lipid metabolism disorders - the influence on laboratory parameters and functional capacity In patients without lipid metabolism disorder, treated with simvastatin 20 mg daily, we noted an improvement, i.e. prolongation of claudication interval and elevation of ankle-brachial pressure index, while in the control group treated only with a diet we observed further deterioration of capacity. In the control group, the parameters of lipid metabolism were statistically significantly worse after six months and this trend remained even in further control visits with HDL cholesterol slightly lowering. In the simvastatin group, a statistically significant decrease of LDL occurred during several months as well as elevation of HDL...
|
|
| |
guest ::
RSS feed.