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Combined treatment of advanced head and neck cancer with radiotherapy and cycooxygenase-2 inhibitors (phase I study)
 Halámka, Magdalena ; Petera, Jiří (advisor) ; Soumarová, Renata (referee) ; Kubeš, Jiří (referee)
Combined treatment of advanced head and neck cancer with radiotherapy and cycooxygenase-2 inhibitors (phase I study) This paper describes the course and presents the outcomes of a original phase I study of combined treatment of advanced head and neck cancer using standard radiotherapeutic technique and COX2 inhibitor (Celebrex) as a potentiating agent. The primary goal of the study was identifying of the maximum tolerated dose of Celebrex for the purpose of further clinical investigation. In the theoretical introduction I present data on the incidence and mortality of HaN cancer worldwide and in the Czech republic, further preclinical data justifying use of Celebrex in combined treatment with radiotherapy. Special emphasis was put on presentation of local data systematically gained in Clinic of Oncology in Ostrava where this study has been conducted. These data include an overview of incidence, mortality, therapeutic methods and treatment toxicity profiles. Since the phase I study as such does not include comparison with control patient group, it is necessary to be aware of local standards. This is the background to establish inclusion criteria for patient recruitment, toxicity evaluation and setting maximum tolerance dose criteria. This study furthermore investigates expression of COX2 in tumor tissue and...
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See also: similar author names
2 Halamka, Marek
2 Halámka, Marek
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