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Erythrocytapheresis in the Treatment of Patients with Hereditary Haemochromatosis
Řeháček, Vít ; Bláha, Milan (advisor) ; Gašová, Zdenka (referee) ; Penka, Miroslav (referee)
BACKGROUND: Hereditary hemochromatosis (HH) is one of the most common hereditary diseases of the Euro-American population. The disease is caused by increased absorption of iron from the intestine, regardless of its current stores in the body. Excess iron is stored in tissues and organs and causes their significant damage. HH treatment consists of regular blood withdrawal, activation of erythropoesis causes the utilization of excess iron and normalization of its reserves. The standard method of blood withdrawal is venipuncture, an alternative method with the possibility of collecting larger red cell volume in one procedure is erythrocytapheresis. The aim of the research was to create a group of patients with newly diagnosed HH, apply erythrocytapheresis, verify their effectiveness, optimize and standardize treatment to reduce ferritin levels in the induction phase of treatment below 50 μg/l and subsequently keep ferritin levels below 100 μg / l in the maintenance phase of treatment. METHODS: The group of patient was created in cooperation with hepatology departments of the Hradec Králové region, by testing related patients with HH and by screening blood donors. For erythrocytapheresis, a Haemonetics MCS+ separator (Haemonetics Corp., Braintree, MA, USA) was used. The SW of MCS+ can modify red cell...
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The Quality and Safety of Transfusion Products - a Study on Critical Aspects of Quality and Important Factors in Quality Control
Zimová, Renata ; Bláha, Milan (advisor) ; Gašová, Zdenka (referee) ; Turek, Petr (referee)
The quality and safety of transfusion products - a study on critical aspects of quality and important factors in quality control Products made from blood (transfusion products and blood derivatives) represent a special group of therapeutic preparations that have specific properties (danger of allergic reactions, transfer of infections etc.). The aim of this study was to show critical points of the process of producing safe, first-rate transfusion preparations at the level reflecting the progress in medicine and technology. Secondary aim was to analyze whether inspections of the State Institute for Drug Control, strict requirements and implementation of EU legislative have influence on the quality of work in blood establishments (BEs) and whether there are some relations between selected BEs with similar characteristics (the size and type of facility) and quality of work as this is presently a heated topic in discussions about restructuralization of transfusion service. The author analyzed her own experience gained during 129 inspections from the view of Good Manufacturing Practice (GMP) in BEs in the Czech Republic and abroad. The survey of results The most frequent and most important shortcomings (key and critical points) in production of transfusion products are parameters described in the chapter...
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Rheohemapheresis (Clinical Importance of Rheological, Technical and Further Hemapheretic Indicators of Effectivity; Side-effects and Economy)
Lánská, Miriam ; Bláha, Milan (advisor) ; Gašová, Zdenka (referee) ; Faber, Edgar (referee)
SUMARY RHEOHEMAPHERESIS - Clinical Importance of Rheological, Technical and Further Hemapheretic Indicators of Effectivity , Side-effects and Economy INTRODUCTION: (Haema)rheopheresis combines the possibilities of haemapheresis (a therapeutic method that is focused on the separation of blood components) and medical rheology (a field of science studying blood fluidity and applying the results of this research to clinical practice in pathological impairments, mainly in the area of microcirculation). The rationale of the effect of rheopheresis (RF): the procedures simultaneously eliminate the exactly defined spectrum of rheologically relevant high-molecular proteins. An immediate pulse reduction of plasma viscosity and viscosity of full blood occurs, which can lead to subsequent permanent "recovery" of the microcirculation with the use of a series of procedures and significantly change the natural course of chronic therapy. RF has been tested in several diseases. This study involves the use of rheopheresis in the dry form of age-related macular degeneration (AMD) and sudden idiopathic sensorineural hearing loss - SISHL. The research was aimed at the optimisation of own modification of rheopheresis, effectivity of procedures, search for the markers of immediate efficacy and prognosis, evaluation of safety and...
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Hemotherapy for patients after the hematopoietic stem cell transplantation
Králová, Jana ; Matějček, Martin (advisor) ; Gašová, Zdenka (referee)
The thesis deals with the issue of application of blood products to patients after the hematopoietic stem cell transplantation. The theoretical part covers the hematopoietic stem cell transplantation, its history, possibilities and types of transplantations, examples of indication focused on tumours of childhood. The following text describes basics of hemotherapy, history of treatment by blood, types of transfusion products and matters related to the application of blood transfusion. Next section is about the specifics of hemotherapy for patients after the hematopoietic stem cell transplantation. The practical part is dedicated to the study about transfusion products administered to paediatric patients after the hematopoietic stem cell transplantation at the University Hospital in Motol. The file consists of the list of patients, who underwent the transplantation during the period from 1.1.2010 to 31.12.2012. The thesis assesses the impact of several factors on the quantities and types of administered transfusion products. The factors include gender, age, diagnosis, type of transplantation (autologous/allogeneic), type of donor (related/unrelated) and type of incompatibility of blood group in the AB0 system. Powered by TCPDF (www.tcpdf.org)
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The Quality and Safety of Transfusion Products - a Study on Critical Aspects of Quality and Important Factors in Quality Control
Zimová, Renata ; Bláha, Milan (advisor) ; Gašová, Zdenka (referee) ; Turek, Petr (referee)
The quality and safety of transfusion products - a study on critical aspects of quality and important factors in quality control Products made from blood (transfusion products and blood derivatives) represent a special group of therapeutic preparations that have specific properties (danger of allergic reactions, transfer of infections etc.). The aim of this study was to show critical points of the process of producing safe, first-rate transfusion preparations at the level reflecting the progress in medicine and technology. Secondary aim was to analyze whether inspections of the State Institute for Drug Control, strict requirements and implementation of EU legislative have influence on the quality of work in blood establishments (BEs) and whether there are some relations between selected BEs with similar characteristics (the size and type of facility) and quality of work as this is presently a heated topic in discussions about restructuralization of transfusion service. The author analyzed her own experience gained during 129 inspections from the view of Good Manufacturing Practice (GMP) in BEs in the Czech Republic and abroad. The survey of results The most frequent and most important shortcomings (key and critical points) in production of transfusion products are parameters described in the chapter...
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