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The history of music journalism from the year 1963 until now
Frýdová, Tereza ; Novotný, David Jan (advisor) ; Turek, Pavel (referee)
Diploma thesis The history of music journalism from the year 1963 until now examines the development of domestic music journalism from the year 1963 to the present in three crucial periods. The first period starts by the year 1963 because at this time the first professional music magazine Melodie in the Czechoslovak socialism republic developed. The second period that I study in my thesis was the 1990s, right after the Velvet Revolution, when many new music magazines were established, led by the magazine Rock & Pop. The third period I study in my thesis are the times after the year 2000 which are characterized by the development of online music journalism and by diminishing role of printed music magazines. In the theoretical part, I briefly describe every period by key historical characteristics and I also describe theirs dominant music magazines. In the last section, where I focus on the present time and the world of Internet, I focus also on the online music journalism as a new crucial field of the 21 century which fundamentally changed the work of music journalists. In the analytical part, I choose important music journalists for each period whose work is linked to the period, and with whom I conducted the interviews. The research method is qualitative research conducted in the form of semi-structured...
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The effect of palmitoylation on biological functions of proteins
Frýdová, Tereza ; Bařinka, Cyril (advisor) ; Pavlíček, Jiří (referee)
Palmitoylation is lipid post-translational modification of proteins. It is one of the most common protein lipidations in eukaryotic cells. Unlike other lipid post-translational modifications, palmitoylation is reversible. Its unique reversibility determines important characteristic of palmitoylation - palmitoylation can be regulated in the similiar way as ubiquitination or phosphorylation. At the same time, palmitoylation regulates interactions between cytosolic and membrane domains. Palmitoylation also plays an important role in the intracellular trafficking. It also affects protein stability and protein-protein interactions. Aberrant palmitoylation is linked to several neurodegenerative diseases, such as Alzheimer's disease or neuronal ceroid lipofuscinosis. Key words: palmitoylation, depalmitoylation, post-translational modification, DHHC protein domain, lipid modification
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