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Tracking the progression of Alzheimer's like-pathology in transgenic rat model TgF344-AD
Foltýnová, Alice ; Telenský, Petr (advisor) ; Němec, Pavel (referee)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting dominantly the elderly and it is the most common cause of dementia. AD is characterized by many pathological events such as amyloid plaques, neurofibrillary tangles, inflammation, neurotransmitter dysregulation and many others. These disruptive processes ultimately lead to synaptic and cell loss which human brain. According to literaure, cell loss in AD is apparent especially in the cortex and hippocampus. However, it is unclear at which timepoint the loss becomes significant and in which other structures. There are many other important structures such as olfactory bulbs or entorhinal cortex where the cell loss has not been fully quantified. With new methods like isotropic fractionator it has become possible for scientists to quantify large number of structures more quickly. Since human brains are not easy to obtain shortly after death, use of transgenic animal models, mostly rodents, is a good way to obtain more information about cell and especially neuronal loss occurring in AD. Key words: Alzheimer's disease, cell loss, isotropic fractionator, hippocampus, neurofibrillary tangles, beta amyloid
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Genetic risk factors of Alzheimer's disease
Foltýnová, Alice ; Telenský, Petr (advisor) ; Čechová, Kateřina (referee)
Alzheimer's disease is a neurodegenerative disorder that mostly affects the elderly population and since our lifespan increases, Alzheimer's disease is one of the most serious diseases of the 21st century. There are two types of Alzheimer's disease, namely familial (FAD) and sporadic Alzheimer's disease (SAD) that differ in the age of onset and contribution of the genetic factors - the familial form is genetically predisposed whereas the genes involved in the sporadic form are perceived as risk factors. However, their clinical manifestation is similar. Alzheimer's disease causes dementia that is characterized by memory loss and a steady decline in the early stages. Unfortunately, there are still many discrepancies regarding Alzheimer's disease and there are multiple approaches in research concerning Alzheimer's disease. One of the possible approaches in finding new mechanisms involved in Alzheimer's disease is in genetics - we can findnew genetic loci involved in this disease and investigate new mechanisms via studying newly identified genes. Key words: sporadic form of AD, familiar form of AD, beta amyloid, apolipoprotein E, amyloid precursor protein, presenilin, genome wide association study
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Sňatkové chování v České republice od počátku 90. let do současnosti
Foltýnová, Alice ; Patočka, Jiří (advisor) ; Heřmanová, Eva (referee)
Cílem této práce bylo popsat a zdůvodnit hlavní trendy sňatkového chování v České republice po roce 1989. První a druhá kapitola je teoretickým vstupem do problému - zákon o rodině, ukazatele, kterými je možno postihnout vývoj v oblasti sňatkového chování, demografický přechod, literatura k tématu a vývoj sňatečnosti ve 20. století. Třetí kapitola se již zabývá samotnou analýzou sňatkového chování v ČR od počátku devadesátých let do současnosti. Čtvrtá část práce je zaměřena na sledování meziregionálních rozdílů a nalezení určitých souvislostí územního rozložení sňatečnosti s dalšími ukazateli. Poslední část práce se věnuje aktuálnímu tématu registrovaného partnerství. Je zde rozebrán zákon č. 115/2006 Sb., o registrovaném partnerství a také úpravy, které bylo, v souvislosti s novým zákonem, nutno provést v zákonech jiných.
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