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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
The influence of branebrutinib on the activity of selected reductases from AKR and SDR superfamilies.
 Fiklíková, Barbora ; Wsól, Vladimír (advisor) ; Matoušková, Petra (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Barbora Fiklíková Supervisor: Vladimír Wsól, Ph.D. Title of diploma thesis: The influence of branebrutinib on the activity of selected reductases from AKR and SDR superfamilies Acute myeloid leukaemia (AML), along with other cancer diseases, is a widespread health problem not just in the Czech Republic but in the entire world. There is no reliable cure, and millions of people die of cancer every year. Anthracycline antibiotics (ANT) such as daunorubicin have been used as the cure for many years in combination with other cytostatics. However, even these drugs have their issues. One of the problems is toxicity for the healthy cells (especially cardiomyocytes) caused by the inhibition of topoisomerase 2β and by the reactive oxygen species (ROS) formation. The other problem is the increasing resistance of the ANT to cancer cells. ANTs are metabolized by carbonyl reducing enzymes to appropriate alcohols with lower effects against cancer cells and more severe toxicity for the heart cells. The inhibition of these enzymes could be used to achieve better therapeutic results. One of the potential inhibitors could be branebrutinib (BRA). It inhibits Bruton tyrosine kinase and is used to cure...
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