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Modification of Isoprenoids
Eignerová, Barbara
Abstract-AJ This PhD work is focused on the development of a new methodology aiming at the introduction of the perfluoroalkylated side-chains into various types of molecules. Synthesis of perfluoroalkylated compounds, owing to their biological properties, is a frequent target of organic chemistry.1 During the last couple of decades a number of different methods enabling the perfluoroalkylation have been developed. Among the classical methods belong procedures based on nucleophilic, electrophilic, or radical reactions.2 Interestingly, only a few examples of a transition metal catalyzed perfluoroalkylation reactions have been reported.3 Despite the fact that many of these methods have wide synthetic applicability, they are not general and search for new procedures is a desirable target. One of the possible and hitherto unexplored methods for the synthesis of perfluoroalkylated compounds is a ruthenium-complex catalyzed alkene cross-metathesis. Potentially, a reaction of a suitable terminal alkene reactant bearing a perfluoroalkylated moiety with the second terminal alkene could give rise to a new and more complex internal alkene. Regarding perfluoroalkylated alkenes suitable for the cross-metathesis reactions, (perfluoroalkyl)propenes can be considered as convenient substrates that can be easily prepared from...
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Suplementary protection certificates for Medicinal Products
Eignerová, Barbara ; Dobřichovský, Tomáš (advisor) ; Žikovská, Petra (referee)
Resume - Supplementary Protection Certificates for Medicinal Products Nowadays, the pharmaceutical industry plays an important role in the world's economy and the pharmaceutical research has a decisive impact on the continuing improvement in public health. The system of patent law is of cardinal significance to the industry because it confers monopolies, for a limited period of time, on using innovations and provides a crucial incentive for basic research activities. Innovative companies require the guaranteed period of market exclusivity afforded by patents in order to sustain drug prices, recoup research and development expenditures and finance the development of new products. Although the availability of a patent protection for chemical and pharmaceutical products has, from a historical perspective, only been reaffirmed in the near past, it has been widely accepted as a global standard mainly through the provisions of the WTO's TRIPS agreement. On the other hand, despite the existence of various international treaties harmonising patent laws, patents have to date in their effects remained strictly limited to individual jurisdictions. Closely bound to the patent system itself are the means of the so-called off-patent protection - supplementary protection certificates and the others, for example market...
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Modification of Isoprenoids.
Eignerová, Barbara ; Kotora, Martin (advisor) ; Kvíčala, Jan (referee) ; Kasal, Alexander (referee)
CHARLES UNIVERSITY IN PRAGUE Faculty of Science Department of Organic and Nuclear Chemistry MODIFICATION OF ISOPRENOIDS Synopsis of PhD Thesis Mgr. Barbara Eignerová Prague 2010 Supervisor: Prof. Martin Kotora Introduction This PhD work is focused on the development of a new methodology aiming at the introduction of the perfluoroalkylated side-chains into various types of molecules. Synthesis of perfluoroalkylated compounds, owing to their biological properties, is a frequent target of organic chemistry.1 During the last couple of decades a number of different methods enabling the perfluoroalkylation have been developed. Among the classical methods belong procedures based on nucleophilic, electrophilic, or radical reactions.2 Interestingly, only a few examples of a transition metal catalyzed perfluoroalkylation reactions have been reported.3 Despite the fact that many of these methods have wide synthetic applicability, they are not general and search for new procedures is a desirable target. One of the possible and hitherto unexplored methods for the synthesis of perfluoroalkylated compounds is a ruthenium-complex catalyzed alkene cross-metathesis. Potentially, a reaction of a suitable terminal alkene reactant bearing a perfluoroalkylated moiety with the second terminal alkene could give rise to a new and...
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Modification of Isoprenoids
Eignerová, Barbara
Abstract-AJ This PhD work is focused on the development of a new methodology aiming at the introduction of the perfluoroalkylated side-chains into various types of molecules. Synthesis of perfluoroalkylated compounds, owing to their biological properties, is a frequent target of organic chemistry.1 During the last couple of decades a number of different methods enabling the perfluoroalkylation have been developed. Among the classical methods belong procedures based on nucleophilic, electrophilic, or radical reactions.2 Interestingly, only a few examples of a transition metal catalyzed perfluoroalkylation reactions have been reported.3 Despite the fact that many of these methods have wide synthetic applicability, they are not general and search for new procedures is a desirable target. One of the possible and hitherto unexplored methods for the synthesis of perfluoroalkylated compounds is a ruthenium-complex catalyzed alkene cross-metathesis. Potentially, a reaction of a suitable terminal alkene reactant bearing a perfluoroalkylated moiety with the second terminal alkene could give rise to a new and more complex internal alkene. Regarding perfluoroalkylated alkenes suitable for the cross-metathesis reactions, (perfluoroalkyl)propenes can be considered as convenient substrates that can be easily prepared from...
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