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Medicinal Plants Used in the Treatment of Cardiovascular Disorders in the Czech Republic - Overview and Consumption Analysis in Years 2015 - 2019
Dubánková, Marianna ; Macáková, Kateřina (advisor) ; Mladěnka, Přemysl (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacognosy Candidate RNDr. Mgr. Marianna Dubánková Consultant doc. Ing. Kateřina Macáková, PhD. Title of Thesis Medicinal Plants Used in the Treatment of Cardiovascular Disorders in the Czech Republic - Overview and Consumption Analysis in Years 2015 - 2019. Medicinal plants still hold their strong position in the therapy of various human diseases, even in the modern era. Seven medicinal plants long known for their use in the treatment of cardiovascular disorders were chosen for this thesis, namely Allium sativum L. (garlic), Crataegus spp. (hawthorn), Digitalis spp. (foxglove), Leonurus cardiaca L. (motherwort), Olea europaea L. (olive), Nigella sativa L. (black cumin), and Viscum album L. (European mistletoe). Their beneficial effects on the cardiovascular system (antioxidant, cardioprotective, vasorelaxant, antiatherosclerotic, antihypertensive, and lipid-lowering actions) were reviewed with an emphasis on information concerning humans. When possible, the mechanism explanation, results of clinical trials, and established dosage range for the respective fields of action are presented. The consumption analysis of the preparations containing the abovementioned medicinal plants was conducted with a total number of...
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Ecotoxicological Screening of the Select Drug II
Dubánková, Marianna ; Macáková, Kateřina (referee) ; Vytlačilová, Jitka (advisor)
Dubánková, M. (2010) - Ecotoxicological Screening of the Select Drug II. Diplomová práce. Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany and Ecology Quinolone antibacterial agents represent a chemically homogenous group of purely synthetic antibiotics which originated in the early 1960s and still play an important role in the antimicrobial chemotherapy. Quinolones (or more specific, fluoroquinolones) are frequently used in human therapy for treatment of both common and serious diseases (they are irreplaceable also against bioterrorist weapons, such as anthrax). Some of the fluoroquinolones are also among the most used veterinary antimicrobials, including their large-scale usage in aquaculture. Only in the Czech Republic, their annual consumption is in the order of millions of defined daily doses (DDD). Fluoroquinolones as entirely synthetic compounds do not have any natural source in the environment - therefore their occurrence in both terrestrial and aquatic ecosystems is the result of human activity. Excluding the direct application to the aquatic environment (prophylaxis and treatment of bacterial diseases in the aquaculture), the most common point of entry of fluoroquinolones into the environment is via the wastewaters. Numerous studies...
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