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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
The importance of the determination of activated partial thromboplastin time and partial thromboplastin sensitivity compared to the lupus anticoagulant, deficiency of coagulation factors and heparin.
 Drábková, Dagmar ; Fátorová, Ilona (advisor) ; Sadílek, Petr (referee)
The importance of the determination of activated partial thromboplastin time and partial thromboplastin sensitivity compared to the lupus anticoagulant, deficiency of coagulation factors and heparin Dagmar Drábková Abstract Activated partial thromboplastin time (aPTT) is coagulation test which detect the disturbances of hemostasis and it is the most common test for monitoring unfractioned heparin therapy. In parcial tromboplastin are present activators of contact phase and phospholipids which can significantly affect the sensitivity of reagents to coagulation factors, lupus anticoagulans and heparin. The objective of this study was firstly to compare the sensitivity of parcial tromboplastins with different origins of fosfolipids and various activators to lupus anticoagulans, to decreased and increased levels of coagulation plasmatic factor VIII and sensitivity to standard heparin. Secondly, according to measured data to determine whether any of the selected reagents is suitable for monitoring heparin while being able to detect deficit of coagulation factors and presence of inhibitor. Determination of aPTT was performed with five different reagents which had various phospholipids and activators. The measurements of aPPT were performed on automatic analyzer BCSXP. From the measured data we have found that...
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1 Drábková, Daniela
1 Drábková, Dominika
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