National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Content of biologically active phenolic compounds in cultivated of species of Vaccinium genus.
CARDOVÁ, Michaela
This bachelor´s thesis includes a knowledge about active biologic compounds from the most common grown species of cranberry (Vaccinium) in the Czech Republic. Active substances have been analyzed in varieties of Vaccinium vitis-idaea like Koralle, Runo bielawskie, Sanna, Sussi, Linnea and Ida. Polyphenols are biomolecules, which are founded in products of plants and there have been proved an antioxidant and anti-inflammatory effects in vivo and in vitro (Chiva-Blanch, 2017). In during of evolution, in plants evolved an ability to produce of secondary polyphenolic metabolites, which weren´t intervened to their growth and development but they are very important for environment, for reproduction strategy and mechanism of protection (Cheynier, 2013). Between polyphenols belong to for examples flavonoids and anthocyanins, which are co-pigment of their property. Next analyzed compound was vitamin C alias ascorbic acid. This substance is simple low-molecular-weight carbohydrate. Synthesis of vitamin C is localized of plants and some species of animal, (Lykkesfeldt, 2014). Ascorbic acid is a good antioxidant, which save organism before ROS (reactive oxygen form) and stimulated immune system. The aim of this study was analyzed the content of quercetin, ascorbic acid and the content of total anthocyanin in six selected varieties of cranberry. The determination as such was performed using high performance liquid chromatography (HPLC) and determination of content of anthocyanin were analyzed by use spectrophotometer for define concentration from absorbance of valid sample. We analyzed all of three mentioned kinds of compounds. The higher results of anthocyanin were analyzed from kind Sussi. Concentration was 617 ? 8.7 mg/kg. In kind of Sanna, the ascorbic acid amount to 110 ? 1.4 mg/kg and there were measured the content of quercetin 1019 ? 36 mg/kg in freeze-dryied material.
Effect of nitrogen free radicals in rats heart under hypoxic condition
Cardová, Michaela ; Žurmanová, Jitka (advisor) ; Neckář, Jan (referee)
Since 1987 when the ability of cells was discovered to produce endogenous NO and its role in vascular vasodilatation was found, NO became to be the subject of examination by many scientists. NO is the important signaling molecule for now occurring in all important organ systems. This work is focused on its functionality in cardiac tissue under hypoxic stimulus. Effect of nitric oxide has been recently considered as cardioprotective, in spite of its known and well documented harmful influence. Most of the cytotoxic effects can be explained by peroxynitrit, which originates in the spontaneous reaction of NO with superoxid. The aim of this work is to summarize the most important effects of nitric oxide in the heart.
Do brothers and sisters of siblings with intelectual disability need the support of social work?
Cardová, Michaela ; Havrdová, Zuzana (advisor) ; Chvátalová, Helena (referee)
This thesis explores the experience and support needs of siblings with a brother or sister with intellectual disability. Through review of what is a quite limited literature and from original qualitative research, involving interviews with siblings, the author examines their social reality, focusing especially on their relationships with their disabled brother or sister and with the wider society. Particular attention is given to identifying to what extent the siblings' lives are influenced by the intellectual disability of their brother or sister. Drawing on the findings of this work, the thesis considers how siblings with intellectually disabled brothers or sisters might get systematic support through social work. The research generates several hypotheses for further research.

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3 CARDOVÁ, Michaela
3 Cardová, Magdalena
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