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National Repository of Grey Literature

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The effect of trabectedin on the cells derived from colorectal carcinoma Bobek, Jaroslav ; Boušová, Iva (advisor) ; Szotáková, Barbora (referee) Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Jaroslav Bobek Supervisor: Doc. PharmDr. Iva Boušová, Ph.D. Supervisor specialist: RNDr. Veronika Skarková, Ph.D. Title od diploma thesis: The effect of trabectedin on the cells derivated from colorectal carcinoma Trabectedin is alkaloid, which occurs naturally in sea tunicate Ecteinascidia turbinata. Its mechanism of action consist of creation complexes with DNA, transcription factors and nuclears proteins. This cause blocade of transcription and defect of repair mechanism of DNA in cell. We can use it in therapy of some types of cancer, in this particular work we was researching influence on colorectal carcinoma. We tested this substance on two cancerous cell lines SW 480 - derivated from primary deposit of adenokarcinoma and SW 620 - metastatic line from lymph nodes from same patient. Prime cell cultures marked as 36B and 39B were secured from patients in University Hospital in Hradec Králové and their following cultivation. Both samples 36B and 39B were derived from the primary colon tumor deposit. On all cell lines was performed cytotoxicity assay and then was individualy calculated IC50. These values were used in migration assay for cells 36B and 39B. After treatment with trabectedin both... Detailed record

See also: similar author names
9	Bobek, Jan
2	Bobek, Jiří
3	Bobek, Josef
4	Bobek, Juraj

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