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Nanofiber membranes as carriers of drugs 6.
Bidmonová, Hana ; Doležal, Pavel (advisor) ; Vachek, Josef (referee)
Rigorous thesis Nanofiber membranes as carriers of drugs 6. Mgr. Hana Bidmonová ABSTRACT Thesis deals with the evaluation of absorption and the release properties of the nanofibre membranes that were prepared using electrospinning of chitosan solution with the contents of 5 % of a drug and covered with polyurethane layer. Thesis brings a survey about the use of nanofibre membranes in pharmacy and medicine, especially their characteristics and application at drug delivery and distribution and in tissue engineering. The ability of three different membranes to accept and release caffeine as a model drug from their structure was investigated. The caffeine was incorporated into the membranes in company Elmarco, Liberec, or it was impregnated in the membranes using absorption from solutions containing drug. A hypothesis concerned with ability of membranes to accept a part of caffeine by another mechanism than an amount incorporated before electrospinning was confirmed. All of three membranes were immersed in media containing caffeine and they adsorbed the drug in quantity dependent on the sort of liquid medium. At the use of the chloroform dispersions of caffeine, membranes adsorbed more then a mass of membranes themselves. In the set of release experiments of membranes the released amount of caffeine...
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Nanofiber membranes as carriers of drugs 6.
Bidmonová, Hana ; Doležal, Pavel (advisor) ; Vachek, Josef (referee)
Rigorous thesis Nanofiber membranes as carriers of drugs 6. Mgr. Hana Bidmonová ABSTRACT Thesis deals with the evaluation of absorption and the release properties of the nanofibre membranes that were prepared using electrospinning of chitosan solution with the contents of 5 % of a drug and covered with polyurethane layer. Thesis brings a survey about the use of nanofibre membranes in pharmacy and medicine, especially their characteristics and application at drug delivery and distribution and in tissue engineering. The ability of three different membranes to accept and release caffeine as a model drug from their structure was investigated. The caffeine was incorporated into the membranes in company Elmarco, Liberec, or it was impregnated in the membranes using absorption from solutions containing drug. A hypothesis concerned with ability of membranes to accept a part of caffeine by another mechanism than an amount incorporated before electrospinning was confirmed. All of three membranes were immersed in media containing caffeine and they adsorbed the drug in quantity dependent on the sort of liquid medium. At the use of the chloroform dispersions of caffeine, membranes adsorbed more then a mass of membranes themselves. In the set of release experiments of membranes the released amount of caffeine...
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Nanofiber membranes as carriers of drugs 2. Polyvinylalcohol, chitosan, (D,L) polylactic acid.
Bidmonová, Hana ; Doležal, Pavel (advisor) ; Dittrich, Milan (referee)
1. ABSTRACT Diploma thesis concerns with the evaluation of the basic properties of the nanofibre membranes that are made of polyvinylalcohol, chitosan and (D,L) polylactic acid in connection with their possible use as carriers of drugs. Thesis characterizes electrospinning as a method of production of nonwoven textiles and nanofibre materials, polymers that were used in preparation of the nanofibre membranes under experiments, and testing methods that were used. Transdermal pharmaceuticals declared in the AISLP database were summarized in the connection with their possible use in drug administration. The selected physical characteristics of three chemical types of the nonwoven nanofibre membranes made in laboratories ELMARCO Liberec were investigated. The tensile stress properties, hydrophile-lipophile character of surface and absorption-release properties of the membranes were studied at a permeation in vitro study using caffein as a model drug in the experimental part of my work. Tensile properties of membranes are affected by previous radiation sterilization and direction of testing. General characterization of all membranes was not found. Chitosan membrane becomes firmer material after sterilization and it is also tougher in transverse tensile force. PLA membrane is weak after sterilization and also...
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