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Restrictions in public and private lives of Jews during the Protectorate of Bohemia and Moravia - legal regulations and their practical application
Bačová, Jitka ; Kuklík, Jan (advisor) ; Skřejpková, Petra (referee)
This thesis "Restrictions in public and private lives of Jews during the Protectorate of Bohemia and Moravia - legal regulations and their practical application" deals with how Jews were excluded from public and private life, after the commencement of Nazi occupation, all this taking place legally. The work is concerned with how the exclusion of Jews was legally anchored. This work is arranged systematically, and it is divided into ten chapters. Specifically, the thesis pays attention to the origins of the Protectorate of Bohemia and Moravia and its characteristics, law making in the protectorate, outset of the Solution to the Jewish Question that already appeared in Second Republic, introduction to Jewish politics in the protectorate, definition of the term Jew in the protectorate, exclusion of Jews in public life, racial bans, exclusion of half-Jewish people, as well as husbands or wives of Jews from public life, and concluding with restriction of Jews in private life. Key words Jews Protectorate of Bohemia and Moravia Restrictions in public and private lives
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Interaction of selected antiepileptics with MRP2 transporter
Bačová, Jitka ; Pávek, Petr (advisor) ; Trejtnar, František (referee)
(English version) Purpose: Based on recent studies, which have determinated overexpression of efflux transporter MRP2 in blood-brain barier of patients with refractory epilepsy, it has been suggested that this overexpression could contribute to the farmacoresistance to antiepileptic drugs. The aim of our study was to test substrate affinity of selected antiepileptic drugs. In particular, we focused on phenobarbital, phenytoin, ethosuximide, primidone, valproate, carbamazepin, clonazepam and lamotrigin. Furthermore, the inhibitory potency of these antiepileptic to MRP2 was examined. Methods: To study substrate affinity of tested antiepileptic to MRP2, transport experiments were performed in epithelial cell monolayers cultivated on mikroporous membrane filtres. Particulary, MDCKII cells transfected with cDNA of human MRP2 and, as a control, MDCKII-NeO cells where the expression of MRP2 is supressed, were used. For detection of inhibitory potency of the antiepileptic drugs to MRP2, accumulation assays were carried out on MDCKII-MRP2 and MDCKII-NeO cell lines using calcein as a known fluorescent substrate of MRP2. Results: The tested antiepileptic drugs are neither substrates nor inhibitors of MRP2. Conclusion: Our data do not support the hypothesis that the overexpression of MRP2 in blood- brain...
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