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Development od methods for analysis of interactions of the antiviral drug ritonavir with lanosterol-14- α-demethylase of pathogenic yeasts
Burdová, Tereza ; Heidingsfeld, Olga (advisor) ; Dostál, Jiří (referee)
Ritonavir is an HIV protease inhibitor, and has been used as a part of drug cocktails for highly active antiretroviral therapy (HAART). Oropharyngeal candidiasis is one of the most common opportunistic infections among AIDS patients. The research showed that those who were treated with cocktails containing HIV protease inhibitors including ritonavir suffered from oropharyngeal candidiasis to a much lesser extent than patients who received drugs without protease inhibitors. The reason may be the fact that HIV protease inhibitors also inhibit the proteases of pathogenic yeasts, despite high Ki. Another explanation may be that some of these inhibitors block lanosterol-14-α- demethylase, a key enzyme in the biosynthesis of ergosterol, which is an important component of yeast membranes. Aim of the thesis is the isolation of the microsomal fraction of the pathogenic yeasts Candida albicans and Candida parapsilosis and optimization of methods for analysis of the inhibition of yeast lanosterol-14-α- demethylase by ritonavir. Key words: ritonavir, Candida albicans, Candida parapsilosis, lanosterol-14-α- demethylase, microsomal fraction
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Employment law in times of coronavirus pandemic
Burdová, Tereza ; Pichrt, Jan (advisor) ; Tomšej, Jakub (referee)
Employment law in times of coronavirus pandemic Abstract This thesis on employment law in the coronavirus pandemic focuses on the impact of the pandemic on Czech legislation, presents the author's own view on the issue and offers a comparative view of the legislation of the Slovak Republic, the Federal Republic of Germany and the United Kingdom of Great Britain and Northern Ireland. This thesis takes into account the legal situation from 1 March 2020 to 31 December 2022 and is divided into six chapters. After a general introduction defining basic concepts and briefly summarising the employment legislation of the selected countries, the individual chapters follow and address important employment law topics in the context of the coronavirus pandemic. The second chapter focuses on impediments to work, assessing the various impediments to work related to the coronavirus pandemic on the part of both the employee and the employer, followed by contribution during periods of partial unemployment. The third chapter focuses on the ordering of annual leave as one of the options to deal with a crisis and examines the impact of the pandemic on the regulation of annual leave. Another theme is home working, as the coronavirus pandemic has triggered the rise of various forms of flexible working, with the need to reconcile...
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The history of Land adjustment in our region
BURDOVÁ, Tereza
This bachelor?s thesis deals with the description of the history of land adjustment in our country. It shows different processes and forms of land adjustment in the particular periods of time in the Czech history, namely from the beginning of the colonisation to the beginning of the 20th century. This thesis explains and analyzes the process of colonization, the land reform, the consolidating works etc. The conclusion contains a brief summary and comparison of land adjustment in the Czech Republic and in the European Union countries.
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Švýcarsko a jeho postavení v Evropě
Burdová, Tereza ; Kopřiva, Bohumil (advisor)
The thesis describes a short historical and economical development in Switzerland. It tries to find the reasons of its neutrality and why this state still stands out of the rest of Europe. It also compares the state economical situation on the basis of the macroeconomical indicators with the leaders of the EU: Italy, Germany and France and tries to consider if the entrance in the EU would be for the Swiss profitable.
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