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National Repository of Grey Literature

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Chiroptical spectroscopy as a sensitive tool for the conformational analysis of antimicrobial peptides Kocourková, L. ; Novotná, P. ; Čujová, Sabína ; Čeřovský, Václav ; Urbanová, M. ; Setnička, V. We tested the utilization of electronic and vibrational circular dichroism for the conformational study of antimicrobial peptides on two examples: melectin and antapin in different solutions of liposomes and micelles mimicking bacterial or eukaryotic membranes. The results show significant content of the alpha-helical conformation in an environment mimicking the bacterial membrane, while it was considerably low in the eukaryotic membrane-mimicking environment. Detailed record

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