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Ischemic heart disease-from pathophysiology of ischemic mitral regurgitation to percutaneous coronary intervention
Kočka, Viktor ; Widimský, Petr (advisor) ; Mates, Martin (referee) ; Želízko, Michael (referee)
Ischemic heart disease - from pathophysiology of ischemic mitral regurgitation to percutaneous coronary intervention As. MUDr. Viktor Kočka Summary Ischemic mitral regurgitation (IMR) and myocardial revascularization are from pathophysiological perspective closely linked. We first defined the incidence of IMR in current cardiology to be 129 patients per 1 million population annually. These patients have high mortality of 54% during 5 year follow-up. There is pathophysiological hypothesis of association between myocardial viability and IMR and we have proven this thesis to be correct. The presence of at least 5 viable segments of myocardium is a significant predictor of IMR improvement after revascularization. It is noteworthy that dimension of left ventricle indexed to body surface area is a better predictor of long term prognosis than the hemodynamic significance of IMR. We have also found surprisingly robust association between previous revascularization and better prognosis, even after in average 10 years. Further we have focused on the topic of percutaneous coronary intervention (PCI). Pathophysiology of neointimal hyperplasia (NIH) as a basis of clinical in-stent restenosis was examined on animal model. First, novel nanocrystalline diamond (NCD) coronary stent coating was developed with the help of...
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Ischemic heart disease-from pathophysiology of ischemic mitral regurgitation to percutaneous coronary intervention
Kočka, Viktor ; Widimský, Petr (advisor) ; Mates, Martin (referee) ; Želízko, Michael (referee)
Ischemic heart disease - from pathophysiology of ischemic mitral regurgitation to percutaneous coronary intervention As. MUDr. Viktor Kočka Summary Ischemic mitral regurgitation (IMR) and myocardial revascularization are from pathophysiological perspective closely linked. We first defined the incidence of IMR in current cardiology to be 129 patients per 1 million population annually. These patients have high mortality of 54% during 5 year follow-up. There is pathophysiological hypothesis of association between myocardial viability and IMR and we have proven this thesis to be correct. The presence of at least 5 viable segments of myocardium is a significant predictor of IMR improvement after revascularization. It is noteworthy that dimension of left ventricle indexed to body surface area is a better predictor of long term prognosis than the hemodynamic significance of IMR. We have also found surprisingly robust association between previous revascularization and better prognosis, even after in average 10 years. Further we have focused on the topic of percutaneous coronary intervention (PCI). Pathophysiology of neointimal hyperplasia (NIH) as a basis of clinical in-stent restenosis was examined on animal model. First, novel nanocrystalline diamond (NCD) coronary stent coating was developed with the help of...
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