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The role of Pax6 transcription factor in mouse eye development
Žílová, Lucie ; Kozmík, Zbyněk (advisor) ; Krylov, Vladimír (referee) ; Pavlínková, Gabriela (referee)
The formation of the eye is a multistep process of complex morphogenetic events. It begins with the formation of the optic vesicle (OV) and its subsequent interaction with the overlying head surface ectoderm (SE). Reciprocal interaction between OV and SE evoke lens placode formation within the SE followed by coordinated invagination of both, the lens placode and OV. These events result in formation of lens, retina and retinal pigmented epithelium (RPE) with lens originating from the SE and retina/RPE originating from the OV. Early after the retinal domain is established, retinal progenitor cells start to differentiate in seven retinal cell types that are further stratified in the structure of the retina. The transcription factor Pax6 plays a pivotal role in eye formation in various animal species. In mammals, it is expressed from very early stages of eye development in OV and SE. As Pax6-/- mice are anopthalamic, with eye development arrested at OV/SE stage, much attention has been paid to elucidate the Pax6 function in different eye structures. However, whether and/or how Pax6 regulates the early signaling events leading to eye formation as well as the mechanism by which Pax6 regulates the differentiation of all retinal cell types is still only poorly understood. Using the mouse as a model, we...
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The role of Pax6 transcription factor in mouse eye development
Žílová, Lucie ; Kozmík, Zbyněk (advisor) ; Krylov, Vladimír (referee) ; Pavlínková, Gabriela (referee)
The formation of the eye is a multistep process of complex morphogenetic events. It begins with the formation of the optic vesicle (OV) and its subsequent interaction with the overlying head surface ectoderm (SE). Reciprocal interaction between OV and SE evoke lens placode formation within the SE followed by coordinated invagination of both, the lens placode and OV. These events result in formation of lens, retina and retinal pigmented epithelium (RPE) with lens originating from the SE and retina/RPE originating from the OV. Early after the retinal domain is established, retinal progenitor cells start to differentiate in seven retinal cell types that are further stratified in the structure of the retina. The transcription factor Pax6 plays a pivotal role in eye formation in various animal species. In mammals, it is expressed from very early stages of eye development in OV and SE. As Pax6-/- mice are anopthalamic, with eye development arrested at OV/SE stage, much attention has been paid to elucidate the Pax6 function in different eye structures. However, whether and/or how Pax6 regulates the early signaling events leading to eye formation as well as the mechanism by which Pax6 regulates the differentiation of all retinal cell types is still only poorly understood. Using the mouse as a model, we...
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