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GIS of Černý Důl municipality
Šulcová, Monika ; Ježek, Jiří (referee) ; Bartoněk, Dalibor (advisor)
The object of this thesis is the geographic information system of small town Černý Důl, which includes three cadastre units – Černý Důl, Čistá v Krkonoších and Fořt. The system was introduced on the municipal authority in 2003 and program MISYS by company GEPRO Ltd. is used. In the present this program includes themes relating to the primarily property relations, the real condition of the area and the information about local roads. The property relations in the area represent the cadastral maps digitized from the analogue maps of cadastre units Černý Důl and Fořt and the purpose vector analogue maps of cadastre unit Čistá v Krkonoších, which is completed by the raster land cadastre map with vector definition points of simplified land inventory parcels. Information about the real condition in the area provides orthophotos and technical map containing the surface situation and underground utilities. This thesis includes a description of this geographic information system, its evaluation, an outline of next possibility of development and a description of update of land register dates.
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Spectrophotometric assessment of iron chelation at different pH
Šulcová, Monika ; Mladěnka, Přemysl (advisor) ; Macáková, Kateřina (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Monika Šulcová Supervisor: PharmDr. Přemysl Mladěnka PhD. Title of Thesis: Spectrophotometric assessment of iron chelation at different pH Iron is an essential element for living cells. Dangerous for the organism can be its lack and abundance as well. Therefore, its level must be meticulously regulated. The most common cause of iron overload is the excess supply. The iron overload is mainly brought about frequent use of transfusion or hematologic diseases. Iron toxicity is based on the ability to catalyze the formation of free radicals that modify cellular macromolecules and cause tissue damage. The use of iron chelators is therefore a rational therapy of iron overload conditions. Iron chelators are molecules with different structures sparing the ability of iron binding, which results in iron elimination from the organism and prevent iron accumulation in tissues. It is mainly used for intoxication, but some of them are also used in other indications. Attention is paid to the chemotherapy and the treatment of neurodegenerative diseases. There are many methods for determination of iron levels. Ferrozine method can be successfully used for the assessment of ferrous ions chelation....
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Comparison of Iron Chelating Activity of 8-hydroxyquinolines by Direct Spectrophotometry
Šulcová, Monika ; Mladěnka, Přemysl (advisor) ; Karlíčková, Jana (referee)
in English Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of pharmacology and toxicology Candidate: Monika Šulcová MSc. Consultant: Dr. Přemysl Mladěnka, Ph.D. Name of thesis: Comparison of iron chelating activity of 8-hydroxyquinolines by direct spectrophotometry Iron is a biogenic element needed for cell life. Excess iron can be very dangerous for the organism. Thus iron fate in the organism is meticulously regulated. The iron overload arises mainly as the result of frequent blood transfusion or some hematologic diseases. Toxicity of iron is based on the ability to catalyze the formation of reactive oxygen species. The risk can be reduced by the treatment with iron chelators. Iron chelators are compounds with different structures that are therapeutically used for iron intoxication, but are also examined in the treatment of neurodegenerative diseases, acute myocardial infarction and cancer. The ability to bind iron chelator depends not only on its structure, but also on pH. The aim of this work was to compare iron-chelating activity of 8- hydroxyquinolines (basic substance and its derivatives - 5,7-dichloro derivative cloroxin and 5-chlor-7-iod derivative clioquinol) by direct spectrophotometry and to find out the stoichiometry of their complexes with ferrous/ferric...
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Comparison of Iron Chelating Activity of 8-hydroxyquinolines by Direct Spectrophotometry
Šulcová, Monika ; Mladěnka, Přemysl (advisor) ; Karlíčková, Jana (referee)
in English Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of pharmacology and toxicology Candidate: Monika Šulcová MSc. Consultant: Dr. Přemysl Mladěnka, Ph.D. Name of thesis: Comparison of iron chelating activity of 8-hydroxyquinolines by direct spectrophotometry Iron is a biogenic element needed for cell life. Excess iron can be very dangerous for the organism. Thus iron fate in the organism is meticulously regulated. The iron overload arises mainly as the result of frequent blood transfusion or some hematologic diseases. Toxicity of iron is based on the ability to catalyze the formation of reactive oxygen species. The risk can be reduced by the treatment with iron chelators. Iron chelators are compounds with different structures that are therapeutically used for iron intoxication, but are also examined in the treatment of neurodegenerative diseases, acute myocardial infarction and cancer. The ability to bind iron chelator depends not only on its structure, but also on pH. The aim of this work was to compare iron-chelating activity of 8- hydroxyquinolines (basic substance and its derivatives - 5,7-dichloro derivative cloroxin and 5-chlor-7-iod derivative clioquinol) by direct spectrophotometry and to find out the stoichiometry of their complexes with ferrous/ferric...
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Spectrophotometric assessment of iron chelation at different pH
Šulcová, Monika ; Mladěnka, Přemysl (advisor) ; Macáková, Kateřina (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Monika Šulcová Supervisor: PharmDr. Přemysl Mladěnka PhD. Title of Thesis: Spectrophotometric assessment of iron chelation at different pH Iron is an essential element for living cells. Dangerous for the organism can be its lack and abundance as well. Therefore, its level must be meticulously regulated. The most common cause of iron overload is the excess supply. The iron overload is mainly brought about frequent use of transfusion or hematologic diseases. Iron toxicity is based on the ability to catalyze the formation of free radicals that modify cellular macromolecules and cause tissue damage. The use of iron chelators is therefore a rational therapy of iron overload conditions. Iron chelators are molecules with different structures sparing the ability of iron binding, which results in iron elimination from the organism and prevent iron accumulation in tissues. It is mainly used for intoxication, but some of them are also used in other indications. Attention is paid to the chemotherapy and the treatment of neurodegenerative diseases. There are many methods for determination of iron levels. Ferrozine method can be successfully used for the assessment of ferrous ions chelation....
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GIS of Černý Důl municipality
Šulcová, Monika ; Ježek, Jiří (referee) ; Bartoněk, Dalibor (advisor)
The object of this thesis is the geographic information system of small town Černý Důl, which includes three cadastre units – Černý Důl, Čistá v Krkonoších and Fořt. The system was introduced on the municipal authority in 2003 and program MISYS by company GEPRO Ltd. is used. In the present this program includes themes relating to the primarily property relations, the real condition of the area and the information about local roads. The property relations in the area represent the cadastral maps digitized from the analogue maps of cadastre units Černý Důl and Fořt and the purpose vector analogue maps of cadastre unit Čistá v Krkonoších, which is completed by the raster land cadastre map with vector definition points of simplified land inventory parcels. Information about the real condition in the area provides orthophotos and technical map containing the surface situation and underground utilities. This thesis includes a description of this geographic information system, its evaluation, an outline of next possibility of development and a description of update of land register dates.
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