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Nutritional status of patients with acute leukemia during the oncological treatment
Kupilíková, Veronika ; Šťastná-Marková, Markéta (advisor) ; Křížová, Jarmila (referee)
Acute leukemia is defined as a heterogeneous group of malignant hematopoietic stem cell disorders. The aim of this study was to investigate the extent to which nutritional disorders occur in patients with acute leukemia during the cancer treatment, their severity, the most common causes of weight loss, and the extent to which different forms of nutritional intervention are applied in patients. The research was carried out in the Institute of Haematology and Blood Transfusion, during the hospitalization of patients in the inpatient ward, intensive care unit and transplant unit. The study population consisted of 40 patients diagnosed with acute leukemia. Outcomes from nutritional status screening (MNA questionnaire, BMI, weight, mid arm circumference, calf circumference, BIA, biochemical nutritional parameters), and functional assessment (ECOG PS, Chair-stand test, Hand grip test) were used to process the practical part and answer the research questions. Measurements were performed twice with approximately one month intervals. The study confirmed weight loss since the onset of the disease in 95 % of patients. The dominant cause of weight loss was identified in 80 % as lack of appetite. Nutritional screening by MNA evaluated the patient population with a mean score of 22,8 ± 2,9, referring to the risk...
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Nutritional problems in patients with chronic graft-versus-host disease after allogeneic transplantation of hematopoietic cells
Michková, Petra ; Šťastná-Marková, Markéta (advisor) ; Novák, František (referee)
Introduction: Graft versus host disease (GVHD) is a serious medical complication following allogeneic hematopoietic cell transplantation (allo HSCT). It causes immunodeficiency and several organ damage and decreases survival time at two years after a transplantation. A nutritional intervention should be applied just before the transplantation, because a nutritional status significantly influences the post-transplant complications. A risk of malnutrition or metabolic syndrome can be assessed by several markers. A combination of laboratory, anthropometric, biometric and physical data is suitable for this purpose. In addition, a subjective questionnaire regarding eating habits and physical activity of the patients can be used. Objectives: This thesis deals with the patients with chronic GVHD (cGVHD) following the allo HSCT. The objective was to describe a nutritional status of the patients, to find out in which way a long-term immunosuppressive treatment affects a body composition and to describe the eating habits and the physical activity of these patients. Methods: 31 patients with GVHD and 24 patients after allo HSCT without GVHD participated in the research. A body composition (using bioelectrical impedance) and selected laboratory parameters in patients were assessed. A subjective health...
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