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Aptamers affecting eIF4F subunits
 Kopperová, Dana ; Feketová, Zuzana (advisor) ; Schierová, Michaela (referee)
Eukaryotic translation initiation factor 4F comprises of three subunits - eIF4A, eIF4G and eIF4E. These subunits play a key role in translation initiation. On its surface eIF4G binds other translation factors. eIF4A is RNA dependent helicase that is crucial for translation initiation. Affinity of eIF4E towards cap is enhanced if it is in complex with eIF4G. Specific molecules with high affinity were prepared by Selex. These molecules that bind various surfaces and different molecules in the cell are called aptamers. Aptamer binding eIF4A inhibits ATP hydrolysis. Activity of eIF4G may be affected by more aptamers but all resulting in translation inhibition. Aptamer binding eIF4E also inhibits translation by hindering cap binding. All of these translation factors may be detected in non-standard values in tumors. Aptamers against these proteins might bring a solution in the tumor treatment.
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