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National Repository of Grey Literature

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Inflammation and peripheral metabolism of glucocorticoids Leden, Pavel ; Kment, Milan (advisor) ; Hampl, Richard (referee) ; Kršek, Michal (referee) 10 Abstract Glucocorticoids play an important role in regulation of inflammation and their immunosuppressive effect is widely used for treatment of inflammatory diseases. The biological activity of glucocorticoids depends not only on their plasma concentrations, the number of receptors and the responsiveness of the target cells but also on the local metabolism of glucocorticoids that is predominated by 11β-hydroxysteroid dehydrogenase (11HSD). Two isoforms of 11HSD are known. The isoform 11HSD1 operates in vivo predominantly as a reductase that increases the local concentrations of glucocorticoids by reduction of their 11-oxo derivatives. The isoform 11HSD2 is a pure dehydrogenase that inactivates biologically active glucocorticoids to their inactive 11-oxo derivatives. The published data concerning peripheral metabolism of glucocorticoids during inflammation were obtained mostly in in-vitro studies. The aim of the thesis therefore was: (1) to study peripheral metabolism of glucocorticoids during trinitrobenzensulfonic acid (TNBS) induced colitis in rat. (2) to study peripheral metabolism of glucocorticoids in biopsies from human ulcerative colitis (3) to examine peripheral metabolism of glucocorticoids during dextran sodium sulphate (DSS) induced colitis in rat and (4) to study peripheral metabolism of... Detailed record

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