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Modulation of consequences of ischemia and hypoxia
Nohejlová, Kateryna ; Mareš, Jan (advisor) ; Šonka, Karel (referee) ; Vožeh, František (referee)
Modulation of consequences of ischemia and hypoxia Kateryna Nohejlová (maiden Deykun), MD Abstract It is known from literature that that many types of insults are accompanied by the increase of free radicals level. The models of three pathological states, which are known to be related to the changes in free radicals production, were used for the purposes of the work. These models were also chosen because the intensity of action of pathogenic factor borderlines the threshold of mainly functional CNS disturbances. It was need for the animals to survive the interventions in order use behavioral methods of assessment. For the estimation of the degree of disturbances were used tests of postural motor function and motor learning and spatial orientation. The action of free radicals was evaluated indirectly by application of their scavengers and antioxidants: tempol and melatonin, which act extracellularly as well as intracellularly. Scavengers were administered as prevention, before an insult, and as therapy, after an insult. The results were divided into three sets of experiments: 1. Focal photothrombotic ischemia of sensorimotor cortex: The performance of animals that received tempol treatment did not significantly differ from the animals subjected to plain ischemia in either of tests. Melatonin application...
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