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Copper chelating properties of flavanones
Kantorová, Tereza ; Mladěnka, Přemysl (advisor) ; Spilková, Jiřina (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Departmet of Pharmacology and Toxicology Candidate: Tereza Kantorová, MSc. Consultant: Assoc. Prof. Přemysl Mladěnka, Pharm.D.,PhD. Title of the Rigorous Thesis: Copper chelating properties of flavanones Copper is an essential trace element playing an essential role in our body. As part of couproenzymes, it is involved in many physiological processes. However, at the same time, it also poses a certain risk to the human body. Free copper has the ability to potentiate the formation of reactive oxygen species and thus to promote oxidative stress. Therefore, copper homeostasis must be carefully regulated. Flavanones belong to one of the subclasses of flavonoids. These natural substances are very interesting from a scientific point of view due to their possible various pharmacological effects. In this work, we focused on their copper-chelating properties. Flavanones, which are expect to possess a low potential for side effects, could find application as copper chelators and thus expand the current therapeutic modalities for some diseases associated with copper imbalance (e.g. Wilson's disease, tumors). Four selected flavanones (hesperetin, hesperidin, naringenin and naringin) were tested for their ability to chelate copper ions using two...
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