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National Repository of Grey Literature

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Cholestatic Liver Disease in a Rat Model and the Possibilities for its Control Kohoutek, Lukáš ; Kaška, Milan (advisor) ; Gürlich, Robert (referee) ; Vokurka, Jan (referee) Cholestatic liver disease in a rat model and the possibilities for its control Cholestatic liver disease is accompanied with oxidave stress. That it the reason why decreases antioxidative capacity of liver and increases leaky gut. It causes endotoxemia and expansion of production of cytokines and then forming multiorgan failure. Statins can be the way to protect liver cause of their anti-inflammatory efects. Aims: Aims of this study was to verify effect of statines. The questions are if the statin can be medicament which could prevent to increase of liver disease. The reason of this it will be in the oxidative and inflammatory damage, and if may depent on the time of filling statines and dose of statine. Methods: We have defined four groups of rats. We compared between the rats with laparotomy and with or without ligation of choledochus and with taking fluvastatin or not. We rated the tissue of liver and blood sample, or serum. We rated the degree of demage of liver tissue, the degree of cholestasis and proteosyntetic function of the liver. The rating of effects of fluvastatin depends on quantity of the dose (1 and 5 mg/kg of body weight) and the time of dosing of fluvastatin (1 and 2 weeks). Next scale in the studying of processing in cholestatic liver tissues is studium of mechanism of effects... Detailed record

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