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DNA viral infection in patients following allogeneic transplantation of bone marrow
Hubáček, Petr ; Cinek, Ondřej (advisor) ; Šterzl, Ivan (referee) ; Mayer, Jiří (referee) ; Žák, Pavel (referee)
Infectious complications are very common after haematopoietic stem cell transplantation (HSCT). Beside bacterial and mycotic infections, viral infections are important cause of morbidity and mortality of these patients. Among viral infections, the most common are infections caused by DNA viruses. Between January 2001 and October 2008, we have tested samples from 217 paediatric and 382 adult patients after HSCT. In total, we have tested 15 757 samples (median 31 samples for children, 20 for adult). Among them, there was 14 867 samples of peripheral blood and 890 samples of other biological materials (urine, stool, CSF etc.). Quantity of HSV, VZV, CMV, HHV-6, HHV-7, EBV, adenoviruses of group A-C, BKV and albumin gene was tested using quantitative real-time PCR technology. Results of CMV, HHV-6, HHV-7 and EBV were normalized to 10 000 human genome equivalents. HSV and VZV were detected in minute number of samples. Threshold for virostatic therapy was assessed to 100 normalized viral copies for CMV. This level was crossed in 55 children and 123 adults. Despite the virostatic treatment, symptoms of CMV infections developed in 68 patients. CMV disease, alone or in the consequence of other post-transplant complications, was observed in 20 patients, fatal in 17 of them. In 4 paediatric patients, we have detected...
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Numeric simulation of the turbine rotor surfacing
Durajová, Věra ; Slováček, Marek (referee) ; Daněk, Ladislav (advisor)
The project elaborated in frame of engineering studies, solves the problem of restoration of the damaged hinge groove blades, and the surfacing of cylindrical faces of the SAW method, using additional material TOPCORE 838 B. The turbine rotor is made from steel with high resistance temperature 30CrMoNiV5-11. Based on literature studies and issues surfacing calculation, it was established that will preheat the material. The issue was solved by using simulation program SYSWELD.
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Propagation of inclined cracks to the interface of ceramic laminates
Novotná, Lenka ; Trunec, Martin (referee) ; Chlup, Zdeněk (advisor)
Composite materials with laminated structure provide advantages which are utilised during component design. Low density, temperature and chemical stability are the profitable properties predetermining application of ceramic laminates. The main obstacle for wide spread of ceramic materials is their inherent brittleness. Therefore, in this thesis, the crack propagation in ceramics laminates has been extensively studied. Laminated structures with various volume fractions of components (alumina and zirconia) were prepared by electrophoretic deposition. Evaluation of crack propagation through the interface and determination of basic mechanical properties was conducted on the basis of extensive literature search. Crack deflection originated in both presence of internal stresses and differences in elastic modulus during the crack interface passing was monitored. A special type of specimen geometry was employed with the aim to set arbitrary angle between crack and interface. It was experimentally found that the degree of crack deflection is dependent on entering angle and volume fraction of components. Higher crack deflection was already found in the bulk of the test piece comparing to the test piece surface. The 3D fracture surface reconstruction generated using laser confocal microscopy was used in this detailed crack propagation study. Further basic elastic and strength characteristics of laminates were determined and compared to those obtained from monolithic materials. The validity of the mix rule for elastic characteristics was confirmed by comparing of elastics modulus. The most reliable method for elastic modulus determination was marked the dynamic resonance method due to low scatter and consistency in measurement. The flexural strength of all laminates tends to be close to the flexural strength of the weakest component. Therefore the mix rule is not applicable for flexural strength estimation on the contrary of elastic characteristics. The change of component volume fraction leads only to change of flexural strength scatter. Thanks to gained knowledge about crack propagation and basic characteristic determination will be possible to design ceramic laminates more efficiently for given needs of application.
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Intermezzo - Center for Parents and Children
Halbrštátová, Lada ; Havířová, Zdeňka (referee) ; Lavický, Miloš (advisor)
Abstract The main purpose of creating this object was to create a place where people having bad living situation will meet people who live regular lives. This is the reason why two floors were projected. The first floor is designed for social activities whereas the second floor is a housing part with apartments. The advantage of irregular but compact shape of the building is perfect connection between its functional parts. The object does not have any basement and it is placed in a little slopy bulit-up surroundings on the crossing of Tyršova and U Distance streets in Letohrad town. On the first floor there is a main entrance, a coffee, massages, a recreation hall, an art working-room, a gym, changing rooms, administration and the technological background of the object. The second floor does not cover a whole area of the first floor. Apartments, laundry room and drying room are situated here. One of the apartments here is projected as barrier-free as well as whole first floor. Both floors are connected by central staircase with shape of „U“ and an elevator. Roofing of the object is realized by single layered flat roof with classic layer order. The gym is roofed by a flat roof held by glued laminated girders. The construction was projected with regard to synergy of all used materials and systems. The chosen solution of object with two floors (both above the terrain) makes the building pretty marked when looking at it’s location, however it makes the place more integrated and uniform.
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Numeric simulation welding of the turbine vane and rotor
Dohnal, Ivo ; Slováček, Marek (referee) ; Daněk, Ladislav (advisor)
Numeric simulation welding of the turbine vane and rotor - master’s thesis is ordered by the Siemens Industrial Turbomachinery ltd. company. Simulation welding is done in program SYSWELD. Used welding materials are X22CrMoV12-1 (turbine vane), 30CrMoNiV5-11 (rotor), TOPCORE 838 B (additional material). These are temperature-resistant and fire-resistant welding materials. The SYSWELD program works on the principle of finite elements method. By SYSWELD is done the evaluation of temperature and stress fields and material structure after welding. Here is a part , which deals with computations of welding crevices.
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Replacement of headlamp parts screw fixation by a plastic nail
Lysa, Bohuslav ; Píška, Miroslav (referee) ; Polzer, Aleš (advisor)
The master thesis covers several issues linked to a substitution of headlamp screw fixation by a plastic nail. The thesis includes an analysis of the headlamp technology, including description of the prescribed durability tests. On the basis of the analysis some new designs of plastic nails are proposed, consistent with characteristics of plastic materials. Selected outcomes of the analysis have been tested as prototypes and verified with Finite Elements Method in SimDesigner including 3D modeling capabilities provided by the Catia V5. The feasibility study regarding a casting form of the new design of plastic nails and technical economic valuation for contingent assembly mounting is included in the thesis.
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Evaluation of corrosion on selected aluminium alloys
Skýba, Pavel ; Tulka, Jaromír (referee) ; Pacal, Bohumil (advisor)
The thesis focuses on the corrosion research of AlCu4Mg1 aluminium alloys of square shape and sheet metal coated in 99.5% aluminium. The theoretical part deals with the characteristics of aluminium, the classification and naming of aluminium alloys and the impact of admixtures on aluminium alloys. In the following chapter a general introduction to metal corrosion, its differentiation according to the type of corrosion attack, mechanisms of corrosion, the impact of corrosive environment, according to the choice of anti-corrosion protection, etc. is given. The main part is devoted to the corrosion of aluminium with a special importance of the impact of admixtures on aluminium alloys, the types of corrosion attack, the impact of corrosive environment as well as of the anti-corrosion protection of aluminium alloys. The corrosion tests in controlled atmosphere are considered in the next chapter, while the last one deals with the evaluation methodology of the process of corrosion. At the beginning of the experimental part all the used samples and materials are introduced. The thesis continues then with an overview and a description of the methods used for experiments. The measurement procedure and the results of the experiments are presented in the following chapter that focuses on the metallographic analysis of the aluminium alloy samples before the experiment and after the corrosion attack. The main part of the chapter deals with the dependence of corrosion speed of the individual aluminium alloy samples on time after being exposed in the climate chamber and the salt fog chamber
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