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Public procurement at the local government level
ŠTEMBEROVÁ, Štěpánka
The aim of this thesis is to evaluate public procurement practices and elaborate recommended procurement procedures. The resulting part of the work is devoted to a research of selected municipal contracts in terms of volume and structure. It also shows the development of these contracts in the last five years. The research method for achieving the main aim of the work is a case study. Using two real public contracts is demonstrated a possible procurement process. The research via case studies does not serve to produce a generally valid conclusions. However, it is possible to draw several findings from the examples of public contracts. These findings are applicable to other municipal public procurement.
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Comparison of sequence variations in genes of biotransfromation enzymes in some carcinoma
Turková, Lucie ; Tavandzis, Spiros (referee) ; Bóday, Arpád (advisor)
Xenobiotic biotransformation process and its capacity is crucial for xenobiotic chemicals elimination that may cause damage toward cell structures. The effectiveness of the enzymes included in this process depends on the gene variants that encodes them. The aim of this work was to compare certain polymorphisms of selected genes between cases and control groups. Studied polymorphisms were null genotypes of the glutathione S-transferase gene M1 and T1 and the insertion of TA dinucleotide in the promotor region of UDP-glucuronosyl transferase 1A1. The number of cases group was six included patients with colorectal, lung, prostate, breast, pancreatic and head and neck cancer. Total number of analysed individuals was 1 118 for cancer cases and 470 for healthy controls. The control group was divided into two groups, the first one was called general and the second one was called special included healthy individuals with no cancer history in their closest family members. Gilbert syndrome (GS) is caused by homozygous insertion of the TA dinucleotide in the TATA box of the gene UGT1A1 and it causes elevated bilirubin levels. Bilirubin is a potent antioxidant in human body, so the aim was to attest its protective effect toward cancer. We expected lower frequency of GS as a protective factor in the cases groups compared with controls. This hypothesis was confirmed in the breast cancer group (GS frequency 10,0 %) and pancreatic cancer group (GS frequency 11,1 %). In the general and special control groups the frequency of GS was 16,0 % and 15,4 % respectively. Although the other case groups show lower frequency of GS, the results weren´t statistically significant. Null GSTM1 genotype was observed with 50,4 % frequency in the general control groups and with 55,3 % frequency in the special control group. Neither the one of the cases groups hasn´t showed significantly lower percentage of null genotype. Despite expectation we observed statistically significant lower frequency of null genotype in the group of lung and pancreatic cancer group (37,4 % and 39,3 % respectively). According to this study, we can say that the lack of glutathione S-transferase M1 activity is not a risk factor for cancer development. Null genotype of GSTT1 wasn´t identified in both control groups at all. In case groups of breast and prostate cancer, there was only one individual carrying the null GSTT1 genotype. Statistically significant higher frequency of this polymorphism was observed in patients with colorectal cancer (9,7 %), lung cancer (17,2 %), pancreatic cancer (3,0 %) and head and neck cancer (15,9 %). In these groups the lack of glutathion S-transferase T1 activity might be considered as risk factor for cancer development. Nevertheless, for further verification it needs to take more investigation in this field, especially enlarge the number of patient in the case groups of head and neck, lung and pancreatic cancer.
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Web-based application for Czech language e-learning
Lam Van, Duyet ; Vodňanský, Daniel (advisor) ; Zumr, Jiří (referee)
Lack of knowledge of the Czech language means a serious problem for foreigners living in the Czech Republic. Czech language should help them in communication, business, studying, but for some people it is also the necessary condition for obtaining a permanent residence. The aim of this bachelor thesis is to design and implement a web application that should serve as a source of learning the Czech language for foreigners. To achieve this goal, the thesis first deals with the analysis of the existing solutions for Czech language e-learning. A design of a web application, user interface and the structure of the database model is suggested based on the finishing analysis. After designing the web application, its development follows, in which the client/server architecture and selected web technologies including Laravel Framework, jQuery and MySQL database system are used. The output of this work is a detailed web-based application that provides an access to educational lessons, instructions and exercises for users, who need to improve in Czech language. They can test their knowledge and determine their skill level.
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Possible ways to breach the water supply system a draft of the measures to prevent its abuse in South Bohemia.
SOUKUPOVÁ, Eva
The theoretical part of the thesis focuses on the characteristics of water as the basic structural element of the life on the Earth. It also mentions regulations related to critical infrastructure, water protection and water management. It describes water management system of the Czech Republic and the South Bohemian Region. It similarly characterizes the most probable chemical, biological or radiological water contaminants that might be abused by a man in the case of trespassing into waterworks system objects. The aim of the thesis was to map possible threats to the waterworks system and to propose follow-up measures preventing the South Bohemian Waterworks System from abuse. Upon identification of possible threats in the territory of South Bohemia and from the point of view of the extent of the thesis the text then focuses on intentional threat of waterworks object by a man. The research part first deals with more detailed description of the South Bohemia Waterworks System, from drinking water via its pumping, treatment, storage to its supply to final consumers. The system of drinking water supply to inhabitants of South Bohemia is divided into sectors by means of AKIS method here. A questionnaire to employees working in the water management sphere was based on this division and particularly vulnerability and the level of security measures in the individual South Bohemian Waterworks System sectors was evaluated from the information based on their answers. In the second plan the research part of the thesis focuses on description of security elements used in South Bohemian Waterworks System objects accompanied by my own photo documentation of objects and areas administered by the South Bohemian Waterworks Union. The elements of passive and active protection used by the South Bohemian Waterworks Union are documented and described here. Application of two operation analysis methods relates to this part. Quantitative research of security of waterworks objects based on evaluation of the best secured object of the South Bohemian Waterworks System was first performed. The obtained results enable us to determine which of the South Bohemian Waterworks System premises has the best active and passive security against trespass of unauthorized persons. To assess relevancy of the quantitative security research the method of relative comparison of waterworks objects security and its consequent interpretation by the security index is also used. The security index describes object protection against possible trespass within the whole area of the object. Application of this method brings numeric interpretation and identification of the overall security of the South Bohemian Waterworks System with regard to preference of the monitored parameters. The same result is achieved by both the methods. The applied operation analysis methods have revealed that the heart of the South Bohemian Waterworks System, the Plav drinking water treatment plant, the only drinking water treatment plant of South Bohemia supplying majority of South Bohemia inhabitants with drinking water, is the best protected object. Pumping stations and water towers are further well secured objects. There are also completely unsecured object in the South Bohemian Waterworks System. The conclusion contains some measures that should prevent unauthorized persons from trespassing into all waterworks objects and thus protect drinking water against contamination. As the observation has revealed the protection of waterworks objects should be improved with regard to the worsening safety situation in the world. This also involves the costs the South Bohemian Waterworks Union should invest in security to introduce the most up-to-date security elements into practice. We may conclude that the major part of waterworks objects are secured against abuse both passively and actively.
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Radiation-induced cancer in the population of villages around MAPE Mydlovary
KREJČÍ, Klára
In 1959, the building of chemical preparation plant of uranium ore MAPE Mydlovary was initiated in a small village Mydlovary, near České Budějovice. In October 1962, the operation and processing of the uranium ore started. During operation, about 17 million tons of uranium ore were processed and the material from processed uranium ores was stored into the contiguous sludge lagoons. The operation of this plant was terminated in November 1991. The premises of MAPE Mydlovary were partially liquidated, decontaminated and handed over for privatization, nowadays there are recovery and reclamation works in process. Even though, MAPE Mydlovary is nowadays one of the most dangerous strains for environment, which emerged after mining and processing of uranium ores in the Czech Republic. The projection is to liquidate the consequences of this process for many more years from now. In immediate closeness to the premises of MAPE Mydlovary there lie the villages Mydlovary, Olešník and Zahájí. It can be assumed that during the processing of uranium ores and subsequent storing of waste into the contiguous sludge lagoons there could have been some impact on the inhabitants of these villages by radio nuclides. The possibility that there are still some sources of contamination and effect on the inhabitants of the three neighboring villages cannot be excluded nowadays, even after almost 23 years after the shutdown of the plant. For this reason this diploma thesis is dealing with the effects of the preparation plant MAPE Mydlovary on the inhabitants of Mydlovary, Olešník and Zahájí, specifically on the amount of deaths due to cancer diseases of inhabitants of these villages. Data was collected from October 2013 till April 2014 and it includes figures from the period 1971-2010. It was collected using non-standardized interviews and was provided by practicing physicians of the investigated villages; furthermore, data was collected from websites of the Czech Statistical Office. Aim of this thesis was to analyze and compare the deaths due to cancer diseases of the inhabitants in the surroundings of MAPE Mydlovary and of inhabitants in the whole Czech Republic (whole republic´s cancer disease mortality) and evaluate the possible influence of the radiation load on the number of deaths due to cancer diseases of inhabitants in the surroundings of MAPE Mydlovary. The analysis and comparison of the number of deaths was carried out using statistical research. Non parametric testing was used for the statistical research and the so called Fisher exact test was used, which is carried out by means of statistical software www.ncss.com. For this test the level of significance - = 0, 2 was used. The influence of the radiation load on the number of deaths due to cancer diseases is statistically significant only in the village Mydlovary, where it is possible to prove statistically an increased number of deaths due to cancer diseases in comparison to the number of deaths due to cancer diseases in the whole Czech Republic. Based on the evaluation of the obtained data we can state that the chemical preparation plant of uranium ore MAPE Mydlovary most likely had and still may have a negative impact on the inhabitants of the neighboring villages, especially on the inhabitants of the village Mydlovary. For this reason it is very important to continue with the recovery and reclamation works in the premises of the chemical preparation plant of uranium ore MAPE Mydlovary and their main objective is to protect the inhabitants of surrounding villages against possible exposure to the radio nuclides. Nevertheless, the impacts of processing the former chemical preparation plant of uranium ore MAPE Mydlovary will be eliminated for many more years.
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Care for the oral cavity in a hospitalized patient
CINCIALOVÁ, Kateřina
The term oral hygiene includes a set of measures to prevent the origination of parodont and hard tissues and their progression. These ailments belong to the most common and frequent ones despite the fact they may be prevented by appropriate care and by the proper choice of oral hygiene aids. The most frequent problems are dental decay, dental plaque, gum disease. For each of us, good oral hygiene practicing daily is essential for preventing troubles mentioned above. During hospitalization patients often alter their habits and modes because of the disease and the stay out of home. In patients who are not self-administering and patients with limited capabilities it is the nurse who is in charge of providing the oral hygiene. Each nurse´s priority should be to meet all the patient´s needs and the proper oral hygiene is one the basic ones. I set four aims in my thesis. The first was to find out patients´view of the oral hygiene level at hospitalization. The second aim was to describe the standards of oral hygiene the particular ward offers the patients. The third aim was to compare opinions of self-administering and non self-administering patients. The fourth aim was to compare the role of a nurse in providing oral hygiene for self-administering and non self-administerin patients. The results of my research confirm the first hypothesis {--} hospitalization brings about changes in oral hygiene. Also the second hypothesis proved to be right {--} during hospitalization oral hygiene worsens in patients because they do not have enough possibilities to carry out all the procedures they are used to. The third hypothesis was confirmed, too. Nurses are familiar with oral hygiene aids and know how to use them. The fourth hypothesis that nurses do not ask patients to tell them what their oral hygiene habits are was true. I conducted the research by the questionnaire method and the method of a stuctured interview. The research samples were nurses and patients in following units - neurological, internal, surgical and orthopaedic - in the České Budějovice hospital, Inc. and in the Tábor hospital. Inc. The results of this research could be used as a feedback for hospital management to help improve patients´oral hygiene. It is necessary to take some measures in this respect. Nurses should be more active in getting information about patients´ oral hygiene aids and their hygienic habits. They should ensure the highest patients´comfort possible. Then their efforts will be rewarding.
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Chamber music - development of musicality and creativity
Klinecká, Magdalena ; Tomášek, Jiří (advisor) ; Palkovská, Jana (referee)
This work treats of chamber music in several points of view. First, it deals with chamber music in itself; second, with its relation to the interpret; third, with its reference to the audience. Concerning the relation between the interpret and chamber music, we recognize different stages and levels of its prosecution - by children, pupils, amateurs and professional musicians. Further, we detect the impact of chamber music on a person listening to it. We find the positive influence of that music on diseased or handicapped people. We get knowledge of various competitions for chamber ensembles. In the end we acquaint with playing chamber music within my "initial" family and with an extract from arrangement of folksongs for children.
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Problematika karcinomu čípku, zdravotně sociální dopady onemocnění
MÜLLEROVÁ, Jana
The objective of the bachelor thesis focused on this topic was monitoring of the system of prevention and therapy of precanceroses and cervical cancer, including the medicosocial impacts of the disease in a population of Czech women. The studied cohort consisted of women living in the South Bohemian region, Central Bohemia and Prague who underwent the complex treatment of cervical cancer. The experimental part of the thesis was performed using questioning strategy along with data collection using an anonymous questionnaire. Surprisingly, the research implies that most of the women became ill with cervical cancer despite undergoing the gynecological examinations regularly before disease onset. Thus, this prophylactic method was unable to prevent them from the disease development. The amount of information regarding the risk of internal genital cancer is insufficient, even if provided by a gynecologist. The strongest distress associated to the disease was represented by the course of treatment itself, both in somatic and psychic sphere. In half of the cases, the negative impact of treatment on the psyche of the women was confirmed. More than half of the women that underwent the treatment do not work. At the same time, it was revealed that the consequences of the disease have negative effects on intimate life with the partner, however, the partnerships didn{\crq}t break up. The results imply that it is necessary to evaluate and improve the interpretation quality of colposcopic and cytologic examinations at the level of local ambulances. At the moment, the planned vaccination seems to be the best measure in prevention of the disease. It is necessary to promote the level of awareness about the issue, preferably within the framework for sexual health education of girls in the primary schools and consequently during the preventive visits in gynecological ambulances. Based on physician {--} psychologist cooperation, the psychological distress in the course of treatment can be managed by providing psychological counseling already during the hospital treatment. The earlier return of the patient to work can be achieved by integrating the patients into the complex rehabilitation process. Cervical carcinoma represents a serious illness and it should be in the interest of our society to improve and perfect the system of its awareness and prevention.
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Computational modelling of noise inside cabin of aircraft VUT 100 Cobra
Prnka, Jiří ; Houfek, Lubomír (referee) ; Švancara, Pavel (advisor)
This master’s thesis deals with the computational simulation of low-frequency noise inside the cabin of small commercial airplane VUT 100 Cobra. For this low-frequncy range deterministic methods: Final Element Method (FEM) and Boundary Element Method (BEM) are used for simulation of the dynamic behaviour of the object. FEM has been used to compute eigenmodes and eigenfrequences of the structure of the aeroplane cabin and of the acoustic space inside cabin. Then response to harmonic excitation of engine represented by unit forces in place of contact has been computed. Obtained velocities on the surface of the cabin are then used as the basis for the noise calculation inside the cabin using BEM. After that effect of some construction modifications on sound level inside cabin are evaluated by computational modelling.
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Selfmonitoring of Type 1 Diabetes mellitus in adolescents
KORELOVÁ, Andrea
Type 1 diabetes mellitus is a chronic, lifelong disease. The younger the patient, the more seriously the disease affects his (her) childhood. The disease brings about a lot of changes, it involves the loss of freedom and independence. Diabetes makes the normal troubles of adolescence even more difficult. Adolescence is a hard stage of life for patients with the type 1 diabetes mellitus because it is a period when the compensation of diabetes is more difficult than in the previous and following stages of life. Regular self-monitoring is one of the crucial tasks. The selfmonitoring is important for the overall compensation of diabetes and also for the clinical results of treatment. Self-monitoring is the process of monitoring and measurement of one´s own glycemia and ketones in blood and sugar and ketones in urine. It enables the diabetic patient a better orientation in the disease and a certain level of independence. Self-monitoring helps parents gain confidence in cure of their children suffering from diabetes. The theoretical part of my thesis deals with the questions of the type 1 diabetes mellitus and the method of self-monitoring. The objective of the practical part was to survey the subjective view of adolescents with the type 1 diabetes mellitus on self-monitoring and the level of their self-reliance. I set hypotheses suggesting that adolescents perceive self-monitoring to be uncomfortable and cannot cope with the procedures independently. These hypotheses were not confirmed in my research. To get relevant data, I used the questionnaire method. I handed out questionnaires to young patients with diabetes aged 13{--}18 years. A letter for patients´ parents asking for their written consent with the research was attached to the questionnaire.
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