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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Function of systemic right ventricle after atrial correction of transposition of great arteries - longitudinal follow-up and impact on exercise capacity
 Frank Antonová, Petra ; Rohn, Vilém (advisor) ; Linhartová, Kateřina (referee) ; Pudil, Radek (referee)
Function of systemic right ventricle after atrial correction of transposition of great arteries - longitudinal follow-up and impact on exercise capacity Abstract Maximal oxygen uptake during cardiopulmonary exercise test determines decision about pregnancy, therapeutic measures and timing of surgery and heart transplantation. Atrial correction of transposition of great arteries places right ventricle in the systemic positon. The aim of our work was to assess relation of parameters of function of systemic right ventricle to maximal oxygen uptake. 86 patients after Senning correction were subjected to testing of NYHA class, blood tests of NT-proBNP, Holter monitoring and cardiopulmonary exercise test. Systolic function of right ventricle was assessed semiquantitatively by echocardiography and precisely calculated by heart MRI. Maximal oxygen uptake was not associated with NYHA, NT-proBNP nor systolic function of systemic right and subpulmonary left ventricles. The only parameter associated with VO2max was heart rate reserve. Systolic function of the systemic right ventricle is likely only one integral part of a more complex haemodynamic mechanism of total heart output and its increase during exercise. In the second part of our study we aimed to ascertain long term mortality of all patients after atrial...
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Development of cardiovascular system function in patients with a functionally single ventricle
 Materna, Ondřej ; Janoušek, Jan (advisor) ; Klásková, Eva (referee) ; Urbanová, Zuzana (referee)
Development of cardiovascular system function in patients with a functionally single ventricle. Abstract Total cavopulmonary connection (TCPC) is the only possible surgical palliative procedure in patients with a functionally single ventricle. It consists of the stepwise anastomosis of both caval veins with pulmonary arteries, creating a unique situation of so-called Fontan circulation, where the separation of the pulmonary and systemic circuit is traded for chronically elevated systemic venous pressure and impaired cardiac output increase during exercise. We aimed to evaluate long-term results and development of exercise capacity in the population of patients with TCPC in the Czech Republic, possible predictors of their survival and functional outcome, as well as analysis of permanent cardiac resynchronization as one of the new treatment options for dysfunction of the single ventricle. We present a retrospective study of all consecutive patients in the Czech Republic identified in the nationwide single-centre institutional database and matched with the National Death Registry and Cardiovascular Intervention Registries. We proved that overall mean survival probability until composite end-point of death, TCPC take- down or indication for a heart transplant was 92.9 % at 20 years after the operation. TCPC...
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