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Verification of glucose assessment analytical method
ILLEOVÁ, Kateřina
The topic of laboratory accreditation as well as validation and verification of analytical methods has been very current in recent years. Because of the serious impact of analytical results of the measurement on practice, it is required that the results of the analytical measurements were as accurate as possible. This paper deals with the verification of the analytical method determination of glucose, as proof of achieving optimum measurement uncertainties. The verification of spectrofotometric glucose determination was performed using the Cobas Integra 800 analyzer by enzymatic hexokinase method. For the measurement in time the control materials of internal quality control were used and for the measurement in series the control materials of external quality control were used. From the measured values we specified the necessary statistical data (the arithmetic mean, standard deviation, the coefficient of variation, bias, yield) and using these we specified the values of combined and extended uncertainty. The combined uncertainties of both samples shouldn't be higher than 10 %, according to the SEKK association. The combined uncertainty of our first sample was 6.81 % and the second one had 6.45 %. The extended uncertainty of the first sample was 13.62 % and the second one had 12.90 %. From these data, we can conclude that the verification of analytical methods for the determination of glucose succeeded.
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Importace of verification treatment irradiaton position of IMRT prostate
KŘÍŽOVÁ, Marcela
Prostate cancer is the most frequent oncological disease in men. Based on the disease phase and extent, patiens with prostate carcinoma diagnosis are treated with number of different therapies including radical prostatectomy, hormone therapy, chemotherapy, brachytherapy, conventional radiotherapy, conformal radiotherapy and combination of these. This Bachelor Thesis deals with prostate carcinoma treatment using a special conformal radiotherapy method - IMRT (Intensity Modulated Radiotherapy). The first section describes the disease charakter from the clinical point of view and the disease diagnosis, followed by treatment modalities. The main part examines and describes IMRT, treatment planning and resultes from statistic evaluation of irradiation position deviations. IMRT technique allows escalation of the irradiation dose while protecting critical structures. In this way the patient can be irradiated with a total dose of 80 grays (Gy). Patients are irradiated in a linear accelerator. Modulation of the radiation beam using multileaf collimator allows irradiation of different segments of target volume with different doses, so that overal homogenity of the irradiation treatment is achieved through nonhomogenous distribution of the dose. Escalation of the irradiation dose is in a close relationship with the irradiaion position and isocentre position kontrol, so that the treatment quality is guaranteed preventing damane to surrounding healthy tissue. Fixing the patient in irradiation position as well as reproductibility of the position is of essentials importance. The isocentre in irradiation position is verified efore every fraction. Verification portal images are acquired using EPID (Electonic Portal Image Device) Portal Vision LC 250 and then compared with reference verification images acquired by CT when planning the treatment. Portal images are made up of two fields of 12x12 cm size under 0 and 90 or 270 degrees. Deviations are recorded in craniocaudal, mediolateral and anterior-posterior axes, and if they exceed 3mm, the irradiation position is corrected on the irradiation table. In this Thesis, deviations in a group of 30 patients were evaluated using the Aria-Offline Review programme which is an accesory to the treatment planning system. In one third of the statistical group of patient, deviations identified using on offline review were compared with deviations identified by start efore each fraction. Dutiny statistical processing, deviations were recorded within ranges 0-3 mm, 3,1-5 mm and over 5mm. 69% of acceptable deviations were recorded within the 0-3 mm range in the craniocaudal axis, 71% in the mediolateral axis and 67% in the anterior-posterior axis. Based on a complete analysis and evaluation of the deviations we can conclude that verification of the irradiation position in treatment of prostate carcinoma using IMRT is essentials to guarantee the irradiation treatment quality. We have also verified that deviations between 0 and 3 mm are acceptable and in no way impair the treatment quality.
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Educational Programme of Sport Climbing for 6th {--} 9th Classes of Elementary School (composition and verification of methodology of education)
JAKL, Jaroslav
The task of this graduation thesis is a composition and verification of the climbing methodology for pupils of 6th {--} 9th classes of an elementary school. The theoretical part is concerned with the illustration of individual knowledge, skills and technics unnecessary for bouldering. Secondly, the question of safety and suitability of this sport for children of the older school age including frequent mistakes in the teaching methodology as well as climbing itself is dealt. The content of the practical part submits especially fourteen teaching units elaborated in the methodological range and analysis of six chosen verification units realized at two groups of probands including their reflection and expert evaluation of the observer. The main part of verification lessons is documented on a video record, which is instrumental to the retrospective appreciation of the verification lesson process.
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Vyhodnocení nejistoty plošné předpovědi silných konvektivních srážek
Zacharov, Petr, jr. ; Řezáčová, Daniela
Extreme convective events have been studied with numerical weather prediction model LM COSMO (horizontal resolution of 2.8km) and radar data. An ensemble of 13 forecasts, which followed from modyfying initial fields, was created for two of analyzed events. Uncertainty in area-related quantitative precipitation forecast (QPF) was evaluated by fraction skill score (FSS) to quantify an ensemble spread and skill. The spread assesses a difference between a control forecast and ensemble member forecasts and the skill evaluates a difference between a precipitation forecast and radar derived precipitation. The uncertainty analysis shows an effect of forecast lead time and space scale as well as a sensitivity to the area structure of precipitation field. In this paper we summarize our first results dealing with the scale influence on the ensemble spread and skill.
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