guest ::
login
Digital Repository
Search
Submit
Help
About
Home
> Search Results: keywords:"tumor supresorové geny"
Search:
any field
title
authors
keywords
publication date
Institution
document type
conference title
ISBN/ISSN
project number
fulltext
record ID
Search Tips
::
Advanced Search
Search collections:
*** any public collection ***
Agritec
Agrotest fyto, s.r.o.
Agrovýzkum Rapotin Ltd.
Academy of Performing Arts in ...
Academy of Fine Arts in Prague
Analytical and methodological ...
Analysis
Institute of Archaeology, Brno
Institute of Archaeology, Prag...
Architectural Institute in Pra...
Archiv ing. arch. Jana Moučky
Arnika
Czech Water Association
Astronomical Institute
Author works
Bachelor's theses
Banks
Personal bibliographies
Institute of Biophysics
Biology Centre
Institute of Biotechnology
Institute of Botany
Brochures
Newsletters
CENIA
Transport Research Centre
Centre for Transport and Energ...
The Centre for Regional Develo...
Centre for Higher Education St...
Global Change Research Institu...
Czech Association of Occupatio...
Czech Paraplegic Association
The Czech National Bank
Czech Council of Children and ...
Czech Society for Ornithology
Czech University of Life Scien...
Czech Technical University in ...
Czech Statistical Office
CESNET
Travel reports
Hop Research Institute
People in Need Czech Republic
data
National Repository of Grey Li...
Master’s theses
Doctoral theses
doc. RNDr. Jiří Souček, DrSc.
Ekodomov
Institute of Entomology
Institute of Ethnology
European Values o.s.
Fairtrade Czech Republic & Slo...
Charles University Faculties (...
Institute of Pharmacology
Institute of Philosophy
Trade literature
Trade print
Institute of Physics
Institute of Physiology
Galleries
The Gallery of Graphic Arts in...
Gender Studies, o.p.s.
Institute of Geophysics
Department of Geography, Masar...
Institute of Geology
GLE o.p.s.
Grant reports
Habilitation theses
HESTIA
Institute of History
Institute of Hydrobiology
The Arts and Theatre Institute
Iuridicum Remedium
University of South Bohemia in...
South Moravian Museum in Znojm...
Product catalogues
Exhibition catalogues
Department of Social Geography...
Library of the ASCR
Libraries
Conference materials
Culture
Flyers
Literary Academy (Internationa...
The Map Collection at Charles ...
Masaryk University
Masaryk Institute and Archives...
Institute of Mathematics
Mendel University in Brno
Methods
Institute of Microbiology
Ministries
Ministry of Defence
Ministry of Justice
Ministry of the Environment
Monographs
The Moravian Gallery in Brno
Moravian Library
Museums
Museum of the Brno Region
Museum of Glass and Jewellery ...
Museum of Eastern Bohemia in H...
Karel Komárek Proměny Foundati...
National archives
National Film Archive
The National Stud at Kladruby ...
National Information and Co...
National Library of the Czech ...
National Medical Library
National Museum
National Heritage Institute
National Library of Technology
National technical museum
National Institute of Folk Cul...
National Institute for Educati...
The National Museum of Agricul...
National Open-Air Museum
Economics Institute
Nonprofit organizations
Oriental Institute
OSEVA Development and Research...
Personal archives
Miscellaneous
University of Ostrava
The Museum of Czech Literature
Institute of Parasitology
Parliamentary Institute
Biographies
Portfólia
Posters
Postprints
Prague College
Preprints
Papers
Programmes
Promotional and educational ma...
Progress reports
Exhibition guides
Institute of Psychology
Reviews
Rigorous theses
Proceedings
Association for Integration an...
The North Bohemian Museum in L...
SIRIRI
Universities and colleges
Silesian University in Opava
The Silesian Museum
Institute of Slavonic Studies
Institute of Sociology
Institute of Sociology (CVVM)
Private colleges
Specialized departments
Czech Radioactive Waste Reposi...
Statistical reports
Administration
State Office for Nuclear Safet...
Czech Agriculture and Food Ins...
Studies
Technical Museum in Brno
Technical reports
Technology Centre
Thematic collections
Press releases
The Museum of Decorative Arts ...
University of Hradec Králové
Jan Evangelista Purkyně Univer...
Charles University
Palacký University Olomouc
University of Pardubice
Industrial Property Office of ...
Institute of Analytical Chemis...
Institute of Inorganic Chemist...
Institute of Archeological and...
Institute of Vertebrate Biolog...
Institute of Chemical Process ...
Institute of Art History
Institute of Experimental Bota...
Institute of Experimental Medi...
Institute of Photonics and Ele...
J. Heyrovsky Institute of Phys...
Institute of Physical Engineer...
Institute of Atmospheric Physi...
Institute of Physics of Materi...
Institute of Plasma Physics
Institute of Geonics
Institute of Computer Science
Nuclear Physics Institute
Institute of Macromolecular Ch...
Institute of Plant Molecular B...
Institute of Molecular Genetic...
Institute of Organic Chemistry...
Institute of Scientific Instru...
Institute of Czech Literature
Institute of Art History, Char...
Institute of Electrical Engine...
Institute of Hydrodynamics
Institute of the Czech Languag...
Institute for Classical Studie...
Institute of Contemporary Hist...
The Institute for the Study of...
Institute of Soil Biology
Institute of Slavonic-German S...
Institute of State and Law
Institute of Rock Structure an...
Institute of Theoretical and A...
Institute of Information Theor...
Institute of Thermomechanics
Institute of Animal Physiology...
Institutes ASCR
Research
Public universities
Gazettes
Research Institute of Geodesy,...
Scientific research institutio...
Annual reports
University of Chemistry and Te...
University of Economics, Pragu...
The College of European and Re...
The University of Finance and ...
College of Information Managem...
Universities
Brno University of Technology
Academic theses (ETDs)
Research institutes
Research reports
Timber Research and Developmen...
Occupational Safety Research I...
Forestry and Game Management R...
Food Research Institute Prague
Research Institute for Labour ...
Crop Research Institute
The Silva Tarouca Research Ins...
T. G. Masaryk Water Research I...
Woodexpert
University of West Bohemia
Westbohemian Museum in Pilsen
Final reports
Biographies
Reports
Status reports
Survey reports
Sort by:
Display results:
Output format:
latest first
publication date
author
record ID
asc.
desc.
- or rank by -
word similarity
10 results
25 results
50 results
100 results
single list
split by collection
citace
HTML brief
HTML brief + PSH
HTML citesummary
MARC
Refman RIS
National Repository of Grey Literature
10
records found
Search took 0.00 seconds.
Inactivation of tumor suppressor genes contributing to pathogenesis of sporadic cancers.
Zdařilová, Klára
;
Janatová, Markéta
(advisor) ;
Tichá, Ivana
(referee)
Protein product tumor suppressor PALB2 gene plays a major role in pathway of DNA repair of double-strand breaks throught the homologous recombination mechanism. Significance of its pathogenic variants in hereditary forms of breast cancer in BRCA1/2- negative patients in families with multiple breast cancers may be in the Czech Republic comparable with the BRCA2 gene. A role of the PALB2 gene in sporadic breast cancer occurence, which represent 90 - 95 % of all cancers, is still unknown. This thesis focuses on inactivation pathway of tumor suppressor PALB2 in the sporadic breast cancer by a mechanism of allelic loss detecting by loss of heterozygosity (LOH) of corresponding microsatellite markers and hypermethylation of promoter region as the most common mechanisms of inactivation tumor suppressors in early tumorigenesis. In a group of 51 nonselected patients with sporadic breast cancer we found four samples with PALB2 locus allelic loss. These samples were analyzed for somatic mutations. No mutation was found. There is no evidence of promotor hypermethylation in any of the samples. Our data suggest a role of the PALB2 gene inactivation in a minority group of sporadic breast cancers.
Detailed record
Komplexní analýza nádorového supresoru p53 u nehodgkinských lymfomů
Šmardová, Jana
;
Fakultní nemocnice (Brno, Česko)
Detailed record
Senzitivizace B-CLL buněk na cytostatika prostřednictvím monoklonální protilátky rituximab - identifikace zodpovědných proteinů
Trbušek, Martin
;
Fakultní nemocnice (Brno, Česko).
Detailed record
Detekce vrozených mutací antionkogenu p53 u dětských maligních tumorů
Kuklík, Miloslav
;
Fakultní nemocnice v Motole (Praha, Česko)
Detailed record
Molekulárně genetická, imunochemická a funkční analýza antionkogenů ve vztahu k patogeneze solidních nádorů
Bártek, Jiří
;
Bártková, Jiřina
;
Ústav hematologie a krevní transfuze
Detailed record
Přenos genů jako nástroj imortalizace normálních i nádorových epiteliálních buněk a předpoklad genové terapie
Bártková, Jiřina
;
Bártek, Jiří
;
Ústav hematologie a krevní transfuze
Detailed record
RET proto-onkogen v patogenezi medulárního a papilárního karcinomu štítné žlázy u české populace
Bendlová, Běla
;
Endokrinologický ústav
Detailed record
Zavedení a použití nové technologie array-CGH pro přesné určení genových přestaveb u nemocných s akutní myeloidní a lymfoblastickou leukémií
Jarošová, Marie
;
Indrák, Karel
;
Univerzita Palackého
Detailed record
Studium úlohy genetických faktorů v rozvoji nehodgkinských lymfomů
Souček, Pavel
;
Trněný, Marek
;
Státní zdravotní ústav
Detailed record
Studium mechanismu aktivace onkogenů a inaktivace tumor supresorových genů u nehodgkinských lymfomů (NHL) metodou komparativní genomické hybridizace (CGH) a fluorescenční in situ hybridizace (FISH)
Jarošová, Marie
;
Holzerová, Milena
;
Univerzita Palackého
Detailed record
Interested in being notified about new results for this query?
Subscribe to the
RSS feed
.