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Transcranial direct current stimulation in treatment of tinnitus and its psychiatric comorbidity
Mareš, Tadeáš ; Anders, Martin (advisor) ; Klírová, Monika (referee) ; Slovák, Matěj (referee)
The theoretical part of our work is divided into three chapters and provides a contemporary systematic literature review of tinnitus, neurostimulation, and selected neurostimulation methods in its therapy. The first chapter includes an overview of the history, epidemiology, etiopathogenesis, theoretical development models, diagnosis, treatment methods, and comorbidities of tinnitus. The second chapter summarizes the history, principles, practical application, use, and adverse effect profile of the transcranial direct current stimulation (tDCS). The third chapter describes the use of neurostimulation methods in tinnitus therapy, especially synthesizing previous works' knowledge, comparing the protocols used, and identifying the positive influence of the intervals between individual tDCS applications on the therapeutic effects. The research part evaluates the short-term and long-term effects of tDCS on the subjective perception of tinnitus, symptoms of depression and anxiety, and quality of life measured by the use of questionnaires. It is a prospective, randomized, double-blind, placebo- controlled clinical trial of 39 participants diagnosed with chronic, non-pulsatile tinnitus. The research protocol included six applications of bifrontal tDCS in two consecutive weeks, 48 to 72 hours apart, with a...
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Treatment of eating disorders through neurostimulation methods
Baumann, Silvie ; Papežová, Hana (advisor) ; Ustohal, Libor (referee) ; Stárková, Libuše (referee)
Background: Eating disorders are psychiatric illnesses whose treatment is difficult and usually the classic procedures fail. Recently, the number of researches in neuromodulatory methods has increased. I present an overview of basic stimulation methods, their use in the treatment of anorexia nervosa (AN), bulimia nervosa and binge-eating and the results of our study focused on the treatment of AN by transcranial direct current stimulation (tDCS). Methods: It was a randomized, double-blind, sham-controlled trial. Forty-three inpatients with AN were divided to receive either active (n=22) or sham (n=21) tDCS over the left DLPFC (anode F3/cathode Fp2, 2mA for 30 minutes). All patients filled the Eating Disorder Examination Questionnaire (EDE-Q) and Zung depression scale (ZUNG), we measured them the thermal pain threshold, the objective dissatisfaction with their own body by Anamorfic program and evaluated BMI before the first and after the last tDCS. Follow-up was after 2 and 4 weeks. It was evaluated using ANOVA and OPLS model. Results: Compared to sham tDCS, active tDCS improved self-evaluation based on one's body shape (p < 0,05) and significantly decreased the need of excessive control over calorie intake (p < 0,05) in 4-week follow-up (questions 4 and 23 in EDE-Q). Question 21 in EDE-Q was more...
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