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National Repository of Grey Literature 2 records found  Search took 0.02 seconds. 
Účinek perphenazinu na přechodný draslíkový proud u komorových buněk potkana
 Bébarová, M. ; Matejovič, P. ; Pásek, Michal ; Račkauskas, G. ; Šimurdová, M. ; Šimurda, J. ; Nováková, M.
The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 µmol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 µmol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction.
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Model funkce IKto-kanálu komorové buňky potkana
 Pásek, Michal ; Bébarová, M. ; Matejovič, P. ; Šimurda, J.
The paper presents biophysical characteristics of transient outward potassium current (IKto) obtained from experiments on isolated rat ventricular cardiomyocytes. Based on these data a quantitative model of rat IKto was designed
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