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Vliv kreatinu aplikovaného jako potravinový doplněk na exkreci homocysteinu do krve a kyseliny thiodiglykolové do moře
Přistoupilová, K. ; Navrátil, Tomáš ; Šenholdová, Z. ; Přistoupil, T. I. ; Heyrovský, Michael ; Kohlíková, E. ; Petr, M. ; Pelclová, D.
Single-dose food supplementation of creatine (5 g of creatine per day), commonly used by sportsmen, affects their metabolism of thiocompounds and of some compounds in blood and in urine, the metabolism of which is connected with the synthesis of creatine or with its usage in the body. In blood the levels of folates, vitamin B12, homocysteine, triacylglycerols, total cholesterol, LDL cholesterol and HDL cholesterol, uric acid, cortizol, and testosterone were followed. In urine the changes in levels of creatine, creatinine, thiodiglycolic acid (TDGA), and pH were followed. The results were accomplished by data of bioimpedance measurements (body mass, muscle mass, body fat, intra- and extracellular fluids, total body water content, protein content, fitness score). It was found that according to the changes in creatine levels before and after administration of creatine in course of one month, it was possible to divide the subjects under study into four groups.
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Změny koncentrace TDGA v moči jako možný marker metabolismu thiosloučenin
Přistoupilová, K. ; Přistoupil, T. I. ; Šenholdová, Z. ; Navrátil, Tomáš ; Heyrovský, Michael ; Fenclová, Z.
The new simple voltammetric method we described recently, proved already to be useful in determining thiodiglycolic acid (TDGA) levels in urine samples of people influenced by some chemicals, victuals and pharmaceuticals. The present pilot study is a continuation of our previous work devoted to test general feasibility of the method. We concentrated upon time dependent quantitative changes of TDGA excretion into urine of selected volunteers. The TDGA level in all morning samples was the highest in comparison with samples collected during the day. The TDGA level was dependent on the health condition of each person involved. However, a further marked increase of TDGA in the morning urine was observed individually, in general when vitamin B12 had been administered in the evening the day before. Vitamin B12 is known to play an important role in the metabolism of one- and two-carbon units, of homocysteine and of sulfhydryls in general. Certain differences in excretion course of TDGA.
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