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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Effect of early postnatal supplementation by probiotic bacteria Escherichia coli O83:K24:H31 on proportional and fucntional characteristics of selected cellular population
 Věcek, Jan ; Hrdý, Jiří (advisor) ; Funda, David (referee)
The hygiene hypothesis proposes that exposure to microorganisms during the postnatal period is crucial for proper immune system development and may help to prevent development of autoimmune diseases and allergies. Probiotics, live microorganisms with beneficial health effects, could be a safe way to promote the appropriate maturation of the immune system. Early postnatal administration of a specific probiotic strain, Escherichia coli O83:K24:H31 (EcO83), reduces the incidence of allergies later in life. To understand the immunomodulatory features of EcO83, we conducted a bioinformatic analysis of its genome and compared it to two other strains, E. coli Nissle and E. coli K12. Our analysis identified unique genes in EcO83 related to propionate and galactose metabolism, as well as genes that may enhance its ability to thrive in the gastrointestinal tract. Moreover, we transformed EcO83 with luciferase enzymes and observed that it effectively colonizes the gastrointestinal tract of newborn mice but not adult mice. Further analysis of mice treated with EcO83 revealed that the probiotic promotes the expression of genes involved in tight junction formation and increases costimulatory molecules on dendritic cells in the mesenteric lymph nodes (MLN). Induced RORγt+ Tregs in MLN displayed increased...
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