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The characterisation of sperm and seminal plasma glycoproteins: Their role within the tetraspanin network and male fertility
Páleníková, Veronika
Mgr. Veronika Páleníková only to describe the localization and heterodimerization of α3, α6, αV, β1, and β4 integrins in mentioned integrins. Importantly, we detected the presence of integrin β4 subunit in mouse sperm, and characterised that it forms functional heterodimer with α6 subunit. In tion, we described α6β1 and α3β1integrin pairs, which contribute to the integrity and complexity of sperm membranes. Moreover, we found that α6 integrin subunit interacts with proposed CD9 and CD81 as tetraspanin partners for αV integrin in tetraspanin web. Our goal
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The characterisation of sperm and seminal plasma glycoproteins: Their role within the tetraspanin network and male fertility
Páleníková, Veronika ; Postlerová, Pavla (advisor) ; Ryšlavá, Helena (referee) ; Pěknicová, Jana (referee)
Mgr. Veronika Páleníková only to describe the localization and heterodimerization of α3, α6, αV, β1, and β4 integrins in mentioned integrins. Importantly, we detected the presence of integrin β4 subunit in mouse sperm, and characterised that it forms functional heterodimer with α6 subunit. In tion, we described α6β1 and α3β1integrin pairs, which contribute to the integrity and complexity of sperm membranes. Moreover, we found that α6 integrin subunit interacts with proposed CD9 and CD81 as tetraspanin partners for αV integrin in tetraspanin web. Our goal
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Glycoprotein profile of human ejaculate as a marker of its quality
Pavlová, Hana ; Postlerová, Pavla (advisor) ; Krejčová, Tereza (referee)
Glycoproteins are an indispensable component of the sperm glycocalyx. They arise through the process of co-translational or post-translational modification, so-called glycosylation, during which carbohydrate chains are attached to a peptide chain. Glycoproteins are involved in reproductive processes and their presence is often key to successful fertilization. The degree of glycosylation of glycoproteins is highly variable and is determined by the representation of carbohydrate units in glycans. It has already been found that the degree of glycosylation can be related to the fertility of an individual. The diploma thesis is focused on the comparison of the representation of terminal saccharides, sialic acid and fucose, in the glycoproteins of sperm and seminal plasma of patients with normal and abnormal ejaculate parameters. The total rate of sialylation and fucosylation in the seminal plasma was determined, as well as the rate of sialylation and fucosylation of specifically detected glycoproteins of sperm and seminal plasma. A significant difference was noted only in the detection of total fucosylation of seminal plasma glycoproteins. However, subsequent correlation tests revealed important relationship between the degree of sialylation and fucosylation of glycoproteins and ejaculate parameters,...
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