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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Mutation rates and dispersal of human populations
 Kulichová, Iva ; Černý, Viktor (advisor) ; Šolc, Roman (referee)
This bachelor thesis deals with estimation of mutation rate of DNA and its use for dating of the first settlement of Sahul. The first part describes direct approach for the estimation of the mutation rate, based on the analysis of pedigrees and indirect approach based on phylogenetic analysis. The weaknesses of these methods are presented as well, as they distort the resulting values of the mutation rate and therefore it is necessary not to ingore them. Some alternatives of calibration methods for the direct and the indirect estimation of the mutation rate are introduced, for example based on archaeological samples. The subsequent section discusses the characteristic mutation rate of mitochondrial and nuclear DNA estimated utilising the direct and the indirect approach. The difference between pedigree and phylogenetic rates appears especially in the mitochondrial DNA, because of selection.The second part outlines the evolutionary path leading to anatomically modern human in Africa and his expansion into Eurasia based on the fossil record dated 45,000 years ago. Particular attention is paid to the settlement of Sahul in archaeological and molecular point of view. Based on the combination of these sources of information, it is possible to conclude that the settlement of Sahul passed from Africa along...
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