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A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis
Kelíšková, P. ; Matvieiev, O. ; Sokolová, Romana ; Janíková, L. ; Behúl, M. ; Šelešovská, R.
This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both voltammetric and flow amperometric methods. These approaches were effectively used to analyze model solutions, pharmaceutical preparations, and serum samples spiked with GFE, producing accurate results comparable to those obtained with HPLC/DAD analysis. The developed methods provide straightforward, sensitive, and selective means for determining GFE in various sample matrices, underscoring the potential of SP/BDDE in electrochemical analysis.
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Technology of wearable sensors
Javor, Adrián ; Majzlíková, Petra (referee) ; Hubálek, Jaromír (advisor)
This bachelor thesis deals with thick-film and thin-film technology of creating wearable sensors on human body, that sense substances in perspiration. Part is devoted to their classification and making subsequent proposal of flexible three-electrode biosensors using 4 different electrochemical transducers. All of these biosensors sense concentration of lactate in human sweat, and are based on immobilization lactate oxidase enzyme on the working electrode. Technological process of production is based on combination of thick-film and thin-film technology. Conclusion of this bachelor thesis contains amperometric evaluations of the lactate concentration, from which calibration curves were created.
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Characterization of working electrodes of electrochemical sensors modified by carbon nanomaterials
Vančík, Silvester ; Majzlíková, Petra (referee) ; Prášek, Jan (advisor)
This bachelor thesis deals with electrochemical detection of substances using screen-printed electrochemical sensors. The theoretical part describes thick film technology, sensors, selected parts of electrochemistry, voltammetry and carbon nanomaterials. The practical part includes the modification of standard screen-printed electrode by oxygen plasma and spray-coated carbon nanomaterials and its experimental comparison using cyclic voltammetry and scanning electron microscopy. The measured values were processed and evaluated numerically and graphically. In comparison with standard working electrode, the current responses of both electrodes were improved significantly.
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Electrochemical biosensor for glucose detection
Matula, Tomáš ; Majzlíková, Petra (referee) ; Prášek, Jan (advisor)
This thesis pays attention to electrochemical sensors for the detection of glucose. The theoretical part deals with the technology of thick film, their application and firing. It is further described electrochemistry, electrodes used in electrochemistry and analytical methods based on electrochemical reaction. End of theoretical part deals with electrochemical biosensors for detection glucose using special electrodes based on enzyme glucose oxidase. In the experimental part is processed amperometric measure for detection glucose using screenprinted sensors S10 and S8 with immobilized enzyme glucose oxidase. Next was studied effect of plasma, dissolved potassium chloride, storage, ascorbic acid and the reproducibility of the sensors.
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Technology of wearable sensors
Javor, Adrián ; Majzlíková, Petra (referee) ; Hubálek, Jaromír (advisor)
This bachelor thesis deals with thick-film and thin-film technology of creating wearable sensors on human body, that sense substances in perspiration. Part is devoted to their classification and making subsequent proposal of flexible three-electrode biosensors using 4 different electrochemical transducers. All of these biosensors sense concentration of lactate in human sweat, and are based on immobilization lactate oxidase enzyme on the working electrode. Technological process of production is based on combination of thick-film and thin-film technology. Conclusion of this bachelor thesis contains amperometric evaluations of the lactate concentration, from which calibration curves were created.
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Characterization of working electrodes of electrochemical sensors modified by carbon nanomaterials
Vančík, Silvester ; Majzlíková, Petra (referee) ; Prášek, Jan (advisor)
This bachelor thesis deals with electrochemical detection of substances using screen-printed electrochemical sensors. The theoretical part describes thick film technology, sensors, selected parts of electrochemistry, voltammetry and carbon nanomaterials. The practical part includes the modification of standard screen-printed electrode by oxygen plasma and spray-coated carbon nanomaterials and its experimental comparison using cyclic voltammetry and scanning electron microscopy. The measured values were processed and evaluated numerically and graphically. In comparison with standard working electrode, the current responses of both electrodes were improved significantly.
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Electrochemical biosensor for glucose detection
Matula, Tomáš ; Majzlíková, Petra (referee) ; Prášek, Jan (advisor)
This thesis pays attention to electrochemical sensors for the detection of glucose. The theoretical part deals with the technology of thick film, their application and firing. It is further described electrochemistry, electrodes used in electrochemistry and analytical methods based on electrochemical reaction. End of theoretical part deals with electrochemical biosensors for detection glucose using special electrodes based on enzyme glucose oxidase. In the experimental part is processed amperometric measure for detection glucose using screenprinted sensors S10 and S8 with immobilized enzyme glucose oxidase. Next was studied effect of plasma, dissolved potassium chloride, storage, ascorbic acid and the reproducibility of the sensors.
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