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Interaction of HIV-1 infection and expresion of endogenous retroviruses
Machač, David ; Elleder, Daniel (advisor) ; Drda Morávková, Alena (referee)
The aim of this bachelor thesis is to describe the effect of HIV-1 on the expression of HERV proviruses in infected cells, how the presence of HERV transcripts and proteins can affect the replication cycle of HIV-1, the composition, structure and infectivity. These interactions may have negative but also positive effects on HIV-1 infectivity. For example, the mutual presence of HIV-1 and HERV proteins encoded by the gag genes responsible for the capsid, nucleocapsid, and virion matrix, may mix together, and form aberrant capsids that will not play a correct role in the HIV-1 replication cycle. Further, due to the phenomenon called viral pseudotyping, HERV envelope glycoproteins could be incorporated into the HIV-1 membrane. This could be a pathway, how the HIV-1 could theoreticaly extend the tropism to other cells than only CD4 T-lymphocytes, macrophages and dedritic cells. Key Words: HERV, HIV-1, virus pseudotypes, retrovirus replication
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