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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Actin and its regulation in clathrin endocytosis
 Pešanová, Denisa ; Libusová, Lenka (advisor) ; Janštová, Vanda (referee)
4 Abstract Actin filaments and their dynamics play an important role in eukaryotic membrane remodelling. Actin regulatory proteins are required for actin dynamics control. During clathrin-mediated endocytosis actin and regulatory proteins interact with clathrin and adaptors proteins. Together they assist membrane invagination and scission of vesicles. Actin structures are fundamental for formation, internalization and movement of endocytic vesicles in yeast. In mammalian cells, actin is less involved especially in the early stage of endocytosis. Models reflecting different roles of actin in clathrin-mediated endocytosis in yeast and mammals are still lacking despite the latest imaging methods. The goal of this bachelor thesis is to offer a compact summary of controversial observations of actin regulation in endocytosis based on recent studies and simultaneously present selected mechanisms of interactions of the most important proteins, which influence actin dynamics in the clathrin-mediated endocytosis. Key words actin, clathrin-mediated endocytosis, Saccharomyces cerevisiae, regulatory proteins
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Actin and its regulation in clathrin endocytosis
 Pešanová, Denisa ; Libusová, Lenka (advisor) ; Janštová, Vanda (referee)
4 Abstract Actin filaments and their dynamics play an important role in eukaryotic membrane remodelling. Actin regulatory proteins are required for actin dynamics control. During clathrin-mediated endocytosis actin and regulatory proteins interact with clathrin and adaptors proteins. Together they assist membrane invagination and scission of vesicles. Actin structures are fundamental for formation, internalization and movement of endocytic vesicles in yeast. In mammalian cells, actin is less involved especially in the early stage of endocytosis. Models reflecting different roles of actin in clathrin-mediated endocytosis in yeast and mammals are still lacking despite the latest imaging methods. The goal of this bachelor thesis is to offer a compact summary of controversial observations of actin regulation in endocytosis based on recent studies and simultaneously present selected mechanisms of interactions of the most important proteins, which influence actin dynamics in the clathrin-mediated endocytosis. Key words actin, clathrin-mediated endocytosis, Saccharomyces cerevisiae, regulatory proteins
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