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National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Study of the effect of myocardial fibrosis on elemental distribution in rat soft tissues using Laser Ablation ICP-MS
 Machalová, Martina ; Zlámalová Gargošová, Helena (referee) ; Vašinová Galiová, Michaela (advisor)
The most common cause of death in the Czech Republic continue to be cardiovascular diseases. The field of heart failure therapy still keeps moving forward. Yet myocardial fibrosis is one of the consequences and causes of heart failure for which there exists no effective medical care. The solution would be predicting the advancement of fibrosis and a preventive therapy. Many medical methods are being developed now in this regard, and the element distribution in affected tissue could help them. That is the reason why this work centers on the research of the element distribution in rat hearts with an induced myocardial fibrosis. An influence of sample couloration on the analysis was observed during its course. Special attention was paid to the distribution of iron in the fibrotic tissue as well as to the comparisson of the images of myocardial fibrosis. It seems that the iron distribution specificly could be helpful in recognising a damaged myocardium.
Detailed record
Bioapatite as an archive of environmental contaminants
 Křemečková, Pavla ; Doležalová Weissmannová, Helena (referee) ; Vašinová Galiová, Michaela (advisor)
Increasing environmental contamination has become one of the most globally addressed issues in recent years. Skeletal material, whose main mineral component bioapatite is able to accumulate and retain unwanted elements in its structure, can be used to thoroughly understand the impact of contaminants on different environmental components. In the framework of this bachelor thesis, the elemental distribution in the bones of bones of wildlife originating from both contaminated and non-contaminated areas was studied. Using the LA-ICP-MS method, it was possible to detect elements naturally occurring in the bones as well as selected contaminants that were present in higher contents in the bones of the animal from the contaminated area. Also, different techniques used for bone cleaning from soft tissues were tested and based on the results of the experiments performed, it was concluded that the techniques used had no effect on the elemental distribution in the analyzed bones of wild animals.
Detailed record
Study of the effect of myocardial fibrosis on elemental distribution in rat soft tissues using Laser Ablation ICP-MS
 Machalová, Martina ; Zlámalová Gargošová, Helena (referee) ; Vašinová Galiová, Michaela (advisor)
The most common cause of death in the Czech Republic continue to be cardiovascular diseases. The field of heart failure therapy still keeps moving forward. Yet myocardial fibrosis is one of the consequences and causes of heart failure for which there exists no effective medical care. The solution would be predicting the advancement of fibrosis and a preventive therapy. Many medical methods are being developed now in this regard, and the element distribution in affected tissue could help them. That is the reason why this work centers on the research of the element distribution in rat hearts with an induced myocardial fibrosis. An influence of sample couloration on the analysis was observed during its course. Special attention was paid to the distribution of iron in the fibrotic tissue as well as to the comparisson of the images of myocardial fibrosis. It seems that the iron distribution specificly could be helpful in recognising a damaged myocardium.
Detailed record

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