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Study of physicochemical aspects influencing the properties of polymer particles
Slowíková, Eliška ; Holas, Ondřej (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradec Kralové Department of Pharmaceutical Technology Supervisor: PharmDr. Ondřej Holas, Ph.D. Student: Eliška Slowíková Title of thesis: Study of physicochemical aspects influencing the properties of polymer particles Polymeric biodegradable nanoparticles find application as carriers in targeted drug delivery, improve the pharmacokinetic profile of the drug and reduce its adverse effects. Macrophages are involved in the development of many inflammatory, autoimmune and other diseases and represent one of the potential therapeutic targets in the treatment of these diseases. For this reason, attention has been paid to the targeted delivery of anti-inflammatory drugs to macrophages using polymeric nanoparticles. The passive targeting of nanoparticles to macrophages is dependent on their physicochemical properties. The use of nanoparticles with negative surface charge, hydrophobic character and size in the range of 100-300 nm is optimal. In this work, dexamethasone-loaded nanoparticles were prepared by the nanoprecipitation method. Five different types of polymer based on polylactic-co- glycolic acid and five different initial concentrations of dexamethasone for each polymer were used to prepare the nanoparticles. The encapsulation efficiency, size,...
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