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Electrochemically Investigated pH-dependent Redox Properties of Copper Complexes of Azamacrocyclic Ligands
Koláčná, Lucie ; Maďar, M. ; Kubíček, V. ; Ludvík, Jiří
Investigated Cu(II) complexes are based on plain or cross-bridged cyclam. The\nelectrochemically inactive cyclam was modified by carboxylate, phosphonate, or phenolate\npendant arms. Cu(II) represents the main redox center of the complexes. Modification of the\nligand causes a changed pattern of complex redox response in buffered aqueous solution.\nIrreversible Cu(II) reduction results in complex decomposition to amalgamated copper and\nligand in excess. After Cu(0) electrochemical in situ re-oxidation, copper and ligand are recomplexed.\nComplexes undergo isomerization, accelerated by increasing the temperature. The\ninfluence of pH on complex isomerization and the reversibility of its reduction was described.
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Design and synthesis of selective manganese(II) chelators
Míka, Luděk ; Kotek, Jan (advisor) ; Tauchman, Jiří (referee)
Title: Design and synthesis of selective manganese(II) chelators Autor: Luděk Míka Department: Department of Inorganic Chemistry, Faculty of Science Supervisor: doc. RNDr. Jan Kotek, Ph.D. Supervisor's e-mail address: modrej@natur.cuni.cz Abstract:Abstract:Abstract:Abstract: The aim of this project is to synthetize new kind of macrobicyclic ligands derived from cross-bridged cyclam for complexation of Mn2+ ions. These complexes may be potentially used as contrast agents in magnetic resonance imaging. Three macrobicyclic ligand with various pendant arms were synthesized. The ability to complex manganese(II) ions were studied by Mass Spectroscopy. Electrochemical properties of manganese(II) complexes with general chelating agents and one synthesized ligand were studied using cyclic voltammetry. Keywords:Keywords:Keywords:Keywords: cross-bridged cyclam, phosphonate, phosphinate, pendant arms, manganese
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Cross-bridged cyclams as manganese(II) chelators
Míka, Luděk ; Kotek, Jan (advisor) ; Vojtíšek, Pavel (referee)
Title: Cross-bridged cyclams as manganese(II) chelators Autor: Bc. Luděk Míka Department: Department of Inorganic Chemistry, Faculty of Science Supervisor: doc. RNDr. Jan Kotek, Ph.D. Supervisor's e-mail address: modrej@natur.cuni.cz Abstract: The aim of this project was to synthesize a new kind of Mn(II) complexes with ligands derived from cross-bridged cyclam. These complexes may be potentially used as contrast agents in magnetic resonance imaging. Six macrobicyclic ligands with various pendant arm were synthesized, three complexes were sucesfully prepared. Electrochemical properties of prepared manganese(II) complexes with synthesized ligands were studied using cyclic voltammetry. Relaxivity of prepared complexes was determined by 1 H NMR spectroscopy. Keywords: cross-bridged cyclam, phosphonate, phosphinate, pendant arms, manganese
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Design and synthesis of selective manganese(II) chelators
Míka, Luděk ; Kotek, Jan (advisor) ; Tauchman, Jiří (referee)
Title: Design and synthesis of selective manganese(II) chelators Autor: Luděk Míka Department: Department of Inorganic Chemistry, Faculty of Science Supervisor: doc. RNDr. Jan Kotek, Ph.D. Supervisor's e-mail address: modrej@natur.cuni.cz Abstract:Abstract:Abstract:Abstract: The aim of this project is to synthetize new kind of macrobicyclic ligands derived from cross-bridged cyclam for complexation of Mn2+ ions. These complexes may be potentially used as contrast agents in magnetic resonance imaging. Three macrobicyclic ligand with various pendant arms were synthesized. The ability to complex manganese(II) ions were studied by Mass Spectroscopy. Electrochemical properties of manganese(II) complexes with general chelating agents and one synthesized ligand were studied using cyclic voltammetry. Keywords:Keywords:Keywords:Keywords: cross-bridged cyclam, phosphonate, phosphinate, pendant arms, manganese
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