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Drug interactions of drugs used in thyroid diseases
Teťáková, Veronika ; Malý, Josef (advisor) ; Marešová, Helena (referee)
Drug interactions of drugs used in thyroid diseases Author: Veronika Teťáková1 Tutor: PharmDr. Josef Malý, Ph.D.1 1 Department of Social and Clinical Pharmacy, Charles University, Faculty of Pharmacy in Hradec Králové Introduction and objectives: Drug interactions are considered to be a significant aspect of pharmacotherapy that can lead to the potentiation of toxicity and side effects of drugs. However, their identification and adequate management of the use of drug combinations hampers a number of obstacles. The aim of this thesis was to summary information about the drug interactions of drugs used in thyroid diseases (levothyroxine, propylthiouracil, thiamazole) and to formulate articles describing the management of interactions in a clinical practice including information for the dispensation of these drugs. To compare the information presented in each database and to determine the degree of conformity between these sources. Methodology: Based on the use of numerous information sources (Micromedex, UpToDate, SPC, Stockley's Drug Interactions) lists of drug interactions of drugs used in thyroid disaeses were established. Information about these interactions were completed by findings from other sources (PubMed®, scientific reports, Google Scholar). The information presented in each of these...
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Risk assessment associated with the release of radioactive iodine from nuclear medicine department during a fire
RAMBOUSKOVÁ, Lucie
Nuclear medicine is the branch of medicine that is used to diagnosis and treatment with radioactive isotopes. Nuclear medicine is one of the least burdensome non-invasive methods of investigation. In contrast to diagnostic radiology, which shows the structure of organs , nuclear medicine provides information not only anatomical , but also on organ functions and metabolism. In many cases it is a unique diagnostic test that can detect the disease or its extent before, and thus increase the chance of successful treatment. When working with open emitters for nuclear medicine department can be assumed that may occur in the expected manner of use of radioactive sources only incident of First Instance ( spilling or splashing radiopharmaceuticals, patient pollution ) and very rarely an emergency occurs the second stage (the loss or theft of resources radiation). An extraordinary event is the third-degree radiation accident with very minimal probability of occurrence. The aim of the Bachelor thesis is to map the distribution and the storage of radioactive iodine in the Department of nuclear medicine of the hospitals in the Czech Republic, to determine the level of knowledge of the medical staff and members of the fire rescue Corps and their application in practice, in the release of radioactive iodine, and assess the degree of risk associated with the release of radioactive iodine in the fire. The hypothesis assumes that the medical staff and members of the fire rescue Corps know how to proceed in cases of leakage of radioactive iodine from the Department of nuclear medicine, and that the level of risks associated with the release of radioactive iodine in the fire is negligible. It is a form of qualitative research, research-questionnaire and interview-driven method. In an interview, polootevřený will be used and the type of closed questions. The research staff of the Department consists of a set of nuclear medicine and the members of the fire rescue Corps. Thesis will be used for more detailed study of the issue. It may also be used in lectures and seminars, health workers, and a fire department Rescue Corps.
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