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Interaction of selected antidepressants with higher plants as a model of environmental contamination
Herčíková, Adéla ; Smrček, Stanislav (advisor) ; Bělonožníková, Kateřina (referee)
In recent years, the study of drug residues in the environment, which appear to be responsible for a number of adverse ecotoxicological effects, has become increasingly important. Psychopharmaceuticals have a prominent place among the pharmaceuticals, the consumption of which is increasing dramatically and it is appropriate to look for ways to remove them from the ecosystem and to assess the possibility of contamination of food chains. This work concerns the study of phytoextraction of psychopharmaceuticals mianserin and olanzapine. Mianserin belongs to the tetracyclic antidepressants (TCAs). It is mainly used to treat depression, anxiety and sleep disorders. Olanzapine belongs to the group of atypical antipsychotics. It is used to treat psychotic conditions such as schizophrenia and schizoaffective disorders. Phytoextraction is an environmentally friendly process that allows the removal of residual concentrations of pollutants from aquatic ecosystems. These pollutants can be released into the environment even after passing through a wastewater treatment plant. Unfortunately, even the treatment of water for drinking purposes cannot completely remove residual concentrations of pharmaceutical substances. This has led to a constant search for new methods of wastewater decontamination. In this work,...
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Embryotoxicity testing of psychopharmacs using the CHEST method
Pavlovič, Ondřej ; Peterka, Miroslav (advisor) ; Maňáková, Eva (referee)
Psychotropic drugs are commonly used group of pharmaceuticals, their main effect is to alter psychic condition, including mental diseases treatment. Symptoms of mental illnesses are more and more common, theref orenumber of patients diagnosed with mental illnes, and thus using psychotropics, is growing stronger. But using psychotropics during gestation is not without risks for mother and embryo itself. However, thanks to the absence of controlled human studies, the knowledge of emrbyotoxic effects of pschotropics is limited to casuistics, reported side effects and animal experimental studies. Many of those studies suggests emrbyotoxic potential of psychotropic drugs, on the other hand, others claim their safety. The goal of this thesis is to test at least some of them, using CHEST method, that allows us to observe direct effect of unmetabolized substance on chick embryo. In this thesis we tested selected psychotropics, very common antidepressant fluoxetine (prozac) and antipsychotic drug olanzapine, for embryotoxicity, using in ovo method CHEST with chick embryos as model organism. By bypassing the maternal organism and his metabolism, this method allows to observe direct effect of unmetabolized substance on chick embryo. Results revealed embryotoxic effect of fluoxetin in dosage 10-2 and 10-3 on 3rd and...
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Embryotoxicity testing of psychopharmacs using the CHEST method
Pavlovič, Ondřej ; Peterka, Miroslav (advisor) ; Maňáková, Eva (referee)
Psychotropic drugs are commonly used group of pharmaceuticals, their main effect is to alter psychic condition, including mental diseases treatment. Symptoms of mental illnesses are more and more common, theref orenumber of patients diagnosed with mental illnes, and thus using psychotropics, is growing stronger. But using psychotropics during gestation is not without risks for mother and embryo itself. However, thanks to the absence of controlled human studies, the knowledge of emrbyotoxic effects of pschotropics is limited to casuistics, reported side effects and animal experimental studies. Many of those studies suggests emrbyotoxic potential of psychotropic drugs, on the other hand, others claim their safety. The goal of this thesis is to test at least some of them, using CHEST method, that allows us to observe direct effect of unmetabolized substance on chick embryo. In this thesis we tested selected psychotropics, very common antidepressant fluoxetine (prozac) and antipsychotic drug olanzapine, for embryotoxicity, using in ovo method CHEST with chick embryos as model organism. By bypassing the maternal organism and his metabolism, this method allows to observe direct effect of unmetabolized substance on chick embryo. Results revealed embryotoxic effect of fluoxetin in dosage 10-2 and 10-3 on 3rd and...
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