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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Synthesis of PME derivatives on nucleobases with conformation locked via pyrrolidine ring
 Rejman, Dominik ; Pohl, Radek
Among diverse nucleoside phosphonic acids, the acyclic phosphonate derivatives have been earlier shown to involve some exceptionally potent antiviral drugs (e.g., Cidofovir, Adefovir, and Tenofovir). This work presents the synthesis of such acyclic phosphonate nucleotides conformationally locked via pyrrolidine ring.
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Piperidine nucleoside phosphonic acid derivatives
 Kovačková, Soňa ; Dračínský, Martin ; Rejman, Dominik
A series of novel phosphonic acid derivatives of piperidine nucleosides was prepared, whereby synthesis of both enantiomeric and diastereomeric derivatives was discussed. Preparation of diphosphate analogs of phosphonic acids derivatives is also described. The prepared nucleotide analogs were tested for their potential biological properties.
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