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Identification of sleep disorders based on actigraphy data and sleep diaries
Molík, Miroslav ; Mekyska, Jiří (referee) ; Mikulec, Marek (advisor)
This master’s thesis deals with prediction of Parkinson's disease using sleep parameters from actigraphy and sleep diaries. The goal is to design a machine learning approach, which will be able to recognize pacients suffering from Parkinson's disease. For training dataset supplied by St. Anne's University Hospital Brno was used, which was variously modified for achieving best possible results. These adjustments were evaluated according to the results of the trained models and based on these results, two models (achieving test accuracies of 85 and 82%) were selected.
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The role of caspase-3 in apoptosis
Kolářová, Karolína ; Tlapáková, Tereza (advisor) ; Anděra, Ladislav (referee)
Caspases provide anti-inflammatory, apoptotic and developmental processes in organisms. They are enzymes with a wide range of activities in all cells, and various pathogeneses can occur if their proper function is disturbed. Since the 1990s, caspases have been a topic of interest for scientists, as their direct link to the triggering of apoptotic processes is a promising possibility for the therapy of diseases related to apoptosis, such as cancer, neurodegenerative diseases, but also cardiac ischemia and diabetes. The cascade of apoptotic processes is controlled by the aforementioned caspases, which are located in the caspase cascade. When the cascade is triggered in a cell, it is due to the presence of a "danger" signal, which can be very different. The most well-known triggers of the apoptotic cascade include activated Fas receptor and FasL ligand, cytochrome c present in the cytoplasm, an imbalance of IAPs in the cell, damaged DNA, and many others. Upon receipt of a signal, initiator caspase-2, caspase-8, and caspase-9 are activated, which in turn activate effector caspases-3, caspase-6, and caspase- 7, cleaving many substrates to promote apoptosis. Thus, caspase-3 is the effector enzyme responsible for the actual execution of apoptosis. However, caspase-3 properties are not only apoptotic, it...
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Case Study of Physiotherapy Treatment of a Patient with Diagnosis morbus Parkinson
Silná, Karolína ; Martínek, Milan (advisor) ; Piruchtová, Karolína (referee)
Title: A case report of physiotherapeutic care for a patient diagnosed with Parkinson's disease. Objective: The aim of this bachelor's thesis in the theoretical part is to provide information on the diagnosis of Parkinson's disease, especially information on etiopathogenesis, diagnosis and treatment. The aim of the practical part is to process a case report of a patient suffering from this diagnosis and evaluate the effect of the performed physiotherapeutic intervention. Method: The general part includes theoretical information about Parkinson's disease in terms of pathophysiology, etiopathogenesis, clinical picture and other areas necessary for a comprehensive understanding of the diagnosis. There is also information on the treatment options for Parkinson's disease, including rehabilitation. The special part contains the case report of a patient diagnosed with Parkinson's disease, which arose within the bachelor's internships at Vršovická Zdravotní. Results: The goals of the theoretical and practical part were met. Following the evaluation of the effect of therapy, it can be concluded that the physiotherapeutic intervention described in the special section had a partial positive effect on the patient's condition. Keywords: Parkinson's disease, neurodegenerative disease, physiotherapy, case report
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Identification of sleep disorders based on actigraphy data and sleep diaries
Molík, Miroslav ; Mekyska, Jiří (referee) ; Mikulec, Marek (advisor)
This master’s thesis deals with prediction of Parkinson's disease using sleep parameters from actigraphy and sleep diaries. The goal is to design a machine learning approach, which will be able to recognize pacients suffering from Parkinson's disease. For training dataset supplied by St. Anne's University Hospital Brno was used, which was variously modified for achieving best possible results. These adjustments were evaluated according to the results of the trained models and based on these results, two models (achieving test accuracies of 85 and 82%) were selected.
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Prions in yeast
Bezdíčka, Martin ; Palková, Zdena (advisor) ; Žíla, Vojtěch (referee)
The thesis describes yeast prions and their biological effects on yeast in general. It defines the basic characteristics of yeast prions, that distinguish prions from other proteins. The thesis introduces various possibilities of prion formation, and propagation as well as specific types of yeast prions, including various functions of most studied types of prions. The thesis also focuses on chaperones that affect the state of yeast prions in cells. Lastly, the thesis indicates similarities between yeast prions and mammalian prions that are related to neurodegenerative diseases. Key words: Yeast prions, features of yeast prions, chaperones, neurodegenerative disease, Saccharomyces cerevisiae
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Prions in yeast
Bezdíčka, Martin ; Palková, Zdena (advisor) ; Žíla, Vojtěch (referee)
The thesis describes yeast prions and their biological effects on yeast in general. It defines the basic characteristics of yeast prions, that distinguish prions from other proteins. The thesis introduces various possibilities of prion formation, and propagation as well as specific types of yeast prions, including various functions of most studied types of prions. The thesis also focuses on chaperones that affect the state of yeast prions in cells. Lastly, the thesis indicates similarities between yeast prions and mammalian prions that are related to neurodegenerative diseases. Key words: Yeast prions, features of yeast prions, chaperones, neurodegenerative disease, Saccharomyces cerevisiae
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