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Formulation and characterization of w/o emulsions for local treatment of musculoskeletal infections
Vedralová, Štěpánka ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Author: Štěpánka Vedralová Title of diploma thesis: Formulation and characterization of w/o emulsions for local treatment of musculoskeletal infections Supervisor: PharmDr. Eva Šnejdrová, Ph.D. The aim of the diploma thesis was to formulate a depot dosage form for the prevention and local treatment of musculoskeletal infections. A water-in-oil emulsions have been formulated which, due to the partition coefficient between the outer and inner phases, can provide sustained drug release. Oils with different viscosities were tested as oil phases. Tricaprin was chosen for the preparation of emulsions, due to the highest stability of the prepared emulsion. Lecithin and sorbitan monooleate or polyglyceryl-3-polyricinooleate (PGPR) and magnesium stearate were used as emulsifiers. The aqueous phase was a solution of vancomycin hydrochloride and gentamicin sulphate. The flow properties on a rotational rheometer were evaluated. The influence of the emulsion composition and the homogenization method on the coefficient of consistency and the index of flow behaviour of the emulsions was studied. The emulsions stabilized with lecithin have a higher viscosity and a structure more sensitive to changes in composition...
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Formulation and characterization of hydrogels for local treatment of musculoskeletal infections
Drdová, Pavlína ; Šnejdrová, Eva (advisor) ; Vraníková, Barbora (referee)
Charles University Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Author: Pavlína Drdová Title of thesis: Formulation and characterization of hydrogels for local treatement of musculoskeletal infection Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Local anti-infective therapy for musculoskeletal infections eliminates systemic drug toxicity. By selecting a suitable drug delivery system, higher drug concentrations at the site of infection and sustained release can be achieved. Such a system may be gels, formulated and tested in the submitted diploma thesis. The theoretical part of the work was devoted to the description of musculoskeletal infections and their treatment, characterization of gels and their use in parenteral administration. Hydrophilic gels based on hypromellose, carrageenan, gelatin and fish gelatin containing vamcomycin hydrochloride and gentamicin sulfate were formulated. Flow and viscoelastic properties were tested on a rotational rheometer. The analysis of flow curves by the Power law model proved a non-Newtonian type of flow. The most sensitive to applied stress is a 3 % hypromellose gel, the least a dispersion of iota-carrageenan with povidone 25. Viscoelastic properties were evaluated based on elastic, viscous and complex modulus, phase angle and yield...
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Formulation and characterization of w/o emulsions for local treatment of musculoskeletal infections
Vedralová, Štěpánka ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Author: Štěpánka Vedralová Title of diploma thesis: Formulation and characterization of w/o emulsions for local treatment of musculoskeletal infections Supervisor: PharmDr. Eva Šnejdrová, Ph.D. The aim of the diploma thesis was to formulate a depot dosage form for the prevention and local treatment of musculoskeletal infections. A water-in-oil emulsions have been formulated which, due to the partition coefficient between the outer and inner phases, can provide sustained drug release. Oils with different viscosities were tested as oil phases. Tricaprin was chosen for the preparation of emulsions, due to the highest stability of the prepared emulsion. Lecithin and sorbitan monooleate or polyglyceryl-3-polyricinooleate (PGPR) and magnesium stearate were used as emulsifiers. The aqueous phase was a solution of vancomycin hydrochloride and gentamicin sulphate. The flow properties on a rotational rheometer were evaluated. The influence of the emulsion composition and the homogenization method on the coefficient of consistency and the index of flow behaviour of the emulsions was studied. The emulsions stabilized with lecithin have a higher viscosity and a structure more sensitive to changes in composition...
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Formulation and characterization of hydrogels for local treatment of musculoskeletal infections
Drdová, Pavlína ; Šnejdrová, Eva (advisor) ; Vraníková, Barbora (referee)
Charles University Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Author: Pavlína Drdová Title of thesis: Formulation and characterization of hydrogels for local treatement of musculoskeletal infection Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Local anti-infective therapy for musculoskeletal infections eliminates systemic drug toxicity. By selecting a suitable drug delivery system, higher drug concentrations at the site of infection and sustained release can be achieved. Such a system may be gels, formulated and tested in the submitted diploma thesis. The theoretical part of the work was devoted to the description of musculoskeletal infections and their treatment, characterization of gels and their use in parenteral administration. Hydrophilic gels based on hypromellose, carrageenan, gelatin and fish gelatin containing vamcomycin hydrochloride and gentamicin sulfate were formulated. Flow and viscoelastic properties were tested on a rotational rheometer. The analysis of flow curves by the Power law model proved a non-Newtonian type of flow. The most sensitive to applied stress is a 3 % hypromellose gel, the least a dispersion of iota-carrageenan with povidone 25. Viscoelastic properties were evaluated based on elastic, viscous and complex modulus, phase angle and yield...
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