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Quality of life in vitiligo patients
Stoklasová, Daniela ; Mareš, Jiří (advisor) ; Kutnohorská, Jana (referee)
Author: Daniela Stoklasová Institution: Department of non-medical studies Faculty od Medicine in Hradec Králové Title: Quality of life in vitiligo patients Supervisor: prof. PhDr. Jiří Mareš, CSc. Number of pages: 106 Year of defense: 2022 Keywords: vitiligo, quality of life, skin, multifactorial disease, nursing care The bachelor's thesis deals with the quality of life of patients with vitiligo. The theoretical part deals with the anatomy and function of the skin. Furthermore, the problems of vitiligo, the causes of this disease, the clinical picture, diagnosis, treatment, similar diseases and autoimmune diseases associated with vitiligo are explained. It also deals with nursing care for these patients and their self-care. Lastly, it clarifies the concept of quality of life, its history, how we generally evaluate quality of life and how we can evaluate it in patients with vitiligo, and also what effect this disease has on the patient's quality of life. The empirical part describes the results of quantitative research, which took place in 52 patients using the Czech version of the VitiQoL questionnaire, which was translated into Czech with the consent of foreign authors. Besides the overall quality of life, this bachelor's thesis focuses on specific areas of quality of life that are highly relevant...
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The impact of acne on everyday life of students in a selected high school
Biňovcová, Anežka ; Hanušová, Jaroslava (advisor) ; Váchová, Alena (referee)
This diploma thesis entitled "The impact of acne on everyday life of students in a selected high school" is divided into two main parts. The first theoretical part is focused on the characteristics of the disease and on the impact of this disease on the quality of life of patients. There is a brief characterization of skin structure, it provides information about pathogenesis of acne and triggering factors, its clinical manifestations and clinical picture. In this part we can also find the diagnosis and treatment options for acne and an overview of other selected facial dermatoses. This part includes the effect of acne on patients' quality of life and an overview of the most common myths about acne. The second part is practically oriented. I used an online questionnaire to find out the impact of acne on everyday life of students in a selected high school. The results of my questionnaire survey show that 12 students (37,5 %) out of 32 respondents suffering from acne (100 %) reached the limit set by me, which determined whether their lives are affected by this disease or not. The first partial goal of the work was to determine the students' knowledge of this disease. I found out that the success rate (evaluated by the number of correct answers) of students in the knowledge part of the questionnaire...
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Epigenetics mechanisms
Šornová, Veronika ; Černá, Marie (advisor) ; Koc, Michal (referee)
Epigenetics is the study of heritable changes in gene activities that are not caused by changes in the DNA sequence. Epigenetic mechanisms can be employed at many levels, from transcription to translation. They include DNA methylation, histone modification, and with it connected chromatin modification, and RNA interference. The result is the change of chromatin conformation leading to decrease or increase of certain gene expression, X-chromosome inactivation or gene imprinting. Epigenetic regulation plays important role in etiopatogenesis of multifactorial diseases. Genetic predisposing factors (in autoimmune diseases there are genes of major histocompatibility complex) and environmental factors, which affect our genome just through epigenetic modifications, are involved in their manifestation. Key words: Epigenetic mechanisms, DNA methylation, histone modification, RNA interference, genomic imprinting, X-chromosome inactivation, multifactorial disease.
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