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Minor forms of spinal muscular atrophy
Metelcová, Tereza ; Šolc, Roman (advisor) ; Daňková, Pavlína (referee)
Spinal muscular atrophy (SMA) is neuromuscular disorder. This disorder affects motor neurons in anterior horns of spinal cord and brainstem, and cause muscle weakness. Some forms of SMA may be cause by damage peripheral nerve. The most significant difference in the pathology of SMA emerging at the level of the spinal cord and peripheral nerves is deterioration of sensory ability. Decreased ability of sensation, due to damage to sensory nerves. Nowadays, it is known 29 forms of SMA, which differ genetically, age of onset of the disorder, severity of symptoms and life expectancy. Mutation of minor forms of SMA is very diverse. Mutated genes are located on 15 different chromosomes, including the X chromosome. Clinical symptoms of SMA is similar in most forms. Several forms has another symptom besides muscular weakness. Nowadays, it is not yet known genetic cause of all forms of SMA
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Minor forms of spinal muscular atrophy
Metelcová, Tereza ; Šolc, Roman (advisor) ; Daňková, Pavlína (referee)
Spinal muscular atrophy (SMA) is neuromuscular disorder. This disorder affects motor neurons in anterior horns of spinal cord and brainstem, and cause muscle weakness. Some forms of SMA may be cause by damage peripheral nerve. The most significant difference in the pathology of SMA emerging at the level of the spinal cord and peripheral nerves is deterioration of sensory ability. Decreased ability of sensation, due to damage to sensory nerves. Nowadays, it is known 29 forms of SMA, which differ genetically, age of onset of the disorder, severity of symptoms and life expectancy. Mutation of minor forms of SMA is very diverse. Mutated genes are located on 15 different chromosomes, including the X chromosome. Clinical symptoms of SMA is similar in most forms. Several forms has another symptom besides muscular weakness. Nowadays, it is not yet known genetic cause of all forms of SMA
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Tactile discrimination and excitability of α-motoneurons
Světlíková, Tereza ; Otáhal, Jakub (advisor) ; Konopková, Renata (referee)
Title of diploma thesis: Tactile discrimination and excitability of alpha motoneurons Objectives: The aim of this thesis is to detect whether tactile discrimination tasks affect the excitability of the alpha motoneurons. Methods: Seven volunteers aged between 20 and 26 years participated in this study. The H reflex, (M wave) were recorded during three control and three experimental conditions. The control conditions preceded each experimental condition. By stimulating the tibialis nerve in the popliteal fossa the H reflex was elicited and its amplitude and latency measured at rest (control) and during tactile discrimination tasks (experimental). As tactile discrimination tasks, three separate tasks were chosen-tactile stimulation, escape reaction to tactile stimulation, and two-point discrimination. We used an EMG stimulator with a constant voltage output and monophasic squared pulses, with a 0,5 ms interval. The stimulation was switched on manually every 3-5 seconds. To detect the electrical potential of the soleus muscle, we used a surface EMG device, a GrassTelefactor, with galvanic isolation complying with EU standards. The parameters measured were the latency and amplitude of the H reflex and M wave during the tactile discrimination tasks and these were then compared to the values at rest. The...
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