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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Carbapenemases and their molecular genetic detection in bacteria causing severe hospital acquired infections
 Vavrová, Jolana ; Dřevínek, Pavel (advisor) ; Zikánová, Blanka (referee)
The aim of this study is to characterize β-lactamases that hydrolyze carbapenems. They belong to molecular classes A, B and D and their new variations are still being identified. The production of enzymes hydrolyzing β-lactam antibiotics is common among Gram-negative bacteria which include also serious nosocomial pathogens such as Pseudomonas aeruginosa, Acinetobacter baumannii or members of Enterobacteriaceae family. The importance of the carbapenemases in clinical practice underlines the fact that carbapenems are broad-spectrum antibiotics, which are considered the reserve antibiotics. An increase in the number of cases of the carbapenem resistance is caused mainly by spread of genes encoding carbapenemases. Detection of carbapenemases and surveillance of their occurrence are both essential not only for optimal management of patients' care, but also for control of the spread of bacterial strains producing carbapenemases.
Detailed record
Carbapenemases and their molecular genetic detection in bacteria causing severe hospital acquired infections
 Vavrová, Jolana ; Dřevínek, Pavel (advisor) ; Zikánová, Blanka (referee)
The aim of this study is to characterize β-lactamases that hydrolyze carbapenems. They belong to molecular classes A, B and D and their new variations are still being identified. The production of enzymes hydrolyzing β-lactam antibiotics is common among Gram-negative bacteria which include also serious nosocomial pathogens such as Pseudomonas aeruginosa, Acinetobacter baumannii or members of Enterobacteriaceae family. The importance of the carbapenemases in clinical practice underlines the fact that carbapenems are broad-spectrum antibiotics, which are considered the reserve antibiotics. An increase in the number of cases of the carbapenem resistance is caused mainly by spread of genes encoding carbapenemases. Detection of carbapenemases and surveillance of their occurrence are both essential not only for optimal management of patients' care, but also for control of the spread of bacterial strains producing carbapenemases.
Detailed record

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